Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 11/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088188 | 1.00 | SLC6A4 (0.56) | SLC6A4JAK2JAK1ABCB1HTR6 | |
| SCHEMBL6088196 | 1.00 | SLC6A4 (0.56) | SLC6A4JAK2JAK1ABCB1HTR6 | |
| SCHEMBL6087454 | 1.00 | SLC6A4 (0.56) | SLC6A4JAK2JAK1ABCB1HTR6 | |
| SCHEMBL6087457 | 1.00 | SLC6A4 (0.56) | SLC6A4JAK2JAK1ABCB1HTR6 | |
| SCHEMBL6088525 | 0.82 | SLC6A4 (0.66) | SLC6A4HTR6HTR1ADRD1SLC6A2 | |
| SCHEMBL6087735 | 0.80 | SLC6A4 (0.64) | SLC6A4HTR6HTR1ADRD1SLC6A2 | |
| SCHEMBL6087915 | 0.73 | SLC6A4 (0.67) | SLC6A4HTR6HTR1ADRD1SLC6A2 | |
| SCHEMBL6086982 | 0.72 | SLC6A4 (1.00) | SLC6A4HTR6HTR1ADRD1SLC6A2 | |
| SCHEMBL6087254 | 0.69 | SLC6A4 (0.62) | SLC6A4HTR6HTR1ADRD1SLC6A2 | |
| SCHEMBL587407 | 0.69 | L3MBTL1 (0.53) | HTR6GPR119ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049314-B2 | Sexual disorders; antidepressants; attention deficit hyperactivity, obsessive-compulsive, and/or post-traumatic stress disorder; drug abuse and addiction | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-23 | — | — | US | disclosed |
| US-20040077705-A1 | Cyclopentyl indole derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077705-A1 | Cyclopentyl indole derivatives | HTR5A, TPH1, TPH2 | SLC6A4 11/4885JAK2 2854/4885JAK1 2372/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.