Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.59 |
| ▸ | RAB9A | P51151 | 11/20 | 0.59 |
| ▸ | MEN1 | O00255 | 9/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.55 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ECE2 | P0DPD6 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10479270 | 0.81 | NPC1 (0.61) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL15550640 | 0.78 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL15550642 | 0.78 | NPC1 (0.67) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11631058 | 0.77 | RAB9A (0.53) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11631054 | 0.77 | RAB9A (0.53) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11630711 | 0.76 | NPC1 (0.55) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL11630715 | 0.76 | NPC1 (0.55) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL8377299 | 0.71 | ALDH1A1 (0.58) | NPC1RAB9AMEN1KMT2AALDH1A1 | |
| SCHEMBL16958749 | 0.71 | NFE2L2 (0.44) | NPC1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL16951406 | 0.71 | NFE2L2 (0.41) | NPC1MEN1KMT2AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |