Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 2/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.53 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 9/20 | 0.40 |
| ▸ | APP | P05067 | 3/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | RXRB | P28702 | 1/20 | 0.40 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.39 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | PTPRB | P23467 | 1/20 | 0.39 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088303 | 0.84 | NOS3 (0.46) | MAOBAPPMAOA | |
| SCHEMBL6088282 | 0.84 | ALOX5 (0.42) | MRGPRX4 | |
| SCHEMBL6089979 | 0.82 | MRGPRX4 (0.41) | NR4A2MAOBMRGPRX4 | |
| SCHEMBL5725097 | 0.82 | CHRNB2 (0.40) | NR4A2NR4A1NR4A3MAOBAPP | |
| SCHEMBL6088875 | 0.82 | MAOB (0.53) | MAOBAPPMRGPRX4 | |
| SCHEMBL6090698 | 0.81 | NR4A2 (0.61) | NR4A2NR4A1NR4A3MAOBRXRA | |
| SCHEMBL6091382 | 0.80 | CCNB2 (0.40) | NR4A2MAOB | |
| SCHEMBL6089097 | 0.80 | FFAR1 (0.45) | NR4A2MAOBMRGPRX4 | |
| SCHEMBL6089755 | 0.79 | TSHR (0.45) | NR4A2MAOBMRGPRX4 | |
| SCHEMBL6088358 | 0.79 | BCHE (0.38) | NR4A2MAOBMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |