Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 3/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 2/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | DRD5 | P21918 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 3/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HTR1F | P30939 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087284 | 0.83 | SLC6A4 (0.54) | SLC6A4IKBKBPARP1DRD2DRD1 | |
| SCHEMBL6087789 | 0.79 | SLC6A4 (0.55) | SLC6A4IKBKBPARP1ADRB2HTR2C | |
| SCHEMBL1413420 | 0.77 | HTR2C (0.58) | IKBKBIDO1ADRB2HTR2CLMNA | |
| SCHEMBL6638279 | 0.74 | SLC6A4 (0.56) | SLC6A4IKBKBADRB2HTR2CHTR1A | |
| SCHEMBL3234820 | 0.74 | SLC6A4 (0.47) | SLC6A4CYP2A6PARP1DRD2DRD1 | |
| SCHEMBL6087540 | 0.72 | IDO1 (0.56) | SLC6A4IKBKBIDO1HTR1A | |
| SCHEMBL6087543 | 0.72 | IDO1 (0.56) | SLC6A4CYP2A6IKBKBIDO1 | |
| SCHEMBL6086622 | 0.70 | SLC6A4 (1.00) | SLC6A4DRD1HTR1A | |
| SCHEMBL23409377 | 0.69 | MAPT (0.38) | IKBKB | |
| SCHEMBL14168901 | 0.69 | HTR2C (0.55) | IKBKBIDO1ADRB2HTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7049314-B2 | Sexual disorders; antidepressants; attention deficit hyperactivity, obsessive-compulsive, and/or post-traumatic stress disorder; drug abuse and addiction | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-05-23 | — | — | US | disclosed |
| US-20040077705-A1 | Cyclopentyl indole derivatives | BRISTOL-MYERS SQUIBB COMPANY | 2004-04-22 | — | — | US | disclosed |
| WO-2004026236-A2 | CYCLOPENTYL INDOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040077705-A1 | Cyclopentyl indole derivatives | HTR5A, TPH1, TPH2 | SLC6A4 11/4885CYP2A6 259/4885IKBKB 320/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.