Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.46 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.46 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2001238 | 0.86 | FABP4 (0.48) | JAK2JAK1FABP4KDM4EGLA | |
| SCHEMBL14470975 | 0.85 | KDM4E (0.51) | PDK1PDK2PDK3PDK4AKR1C3 | |
| SCHEMBL184136 | 0.84 | ALDH1A1 (0.62) | FABP4AKR1C3AKR1C2KDM4EALDH1A1 | |
| SCHEMBL11520956 | 0.82 | FABP4 (0.49) | JAK2JAK1FABP4KDM4EGLA | |
| SCHEMBL4184556 | 0.82 | KDM4E (0.46) | JAK2JAK1FABP4KDM4EGLA | |
| SCHEMBL3441356 | 0.82 | AGTR1 (0.54) | JAK2JAK1KDM4EALDH1A1HPGD | |
| SCHEMBL7023135 | 0.82 | JAK2 (0.43) | JAK2JAK1FABP4PDK1PDK2 | |
| SCHEMBL2492869 | 0.81 | IDO1 (0.47) | JAK2JAK1FABP4KDM4EGLA | |
| SCHEMBL1903514 | 0.81 | KDM4E (0.70) | KDM4EGLAALDH1A1HSD17B10GAA | |
| Hydrochloric Acid SCHEMBL2955045 | 0.81 | KDM4E (0.45) | JAK2JAK1FABP4KDM4EGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560565-B2 | Method for preparing derivatives of 3-hydroxypicolinic acid | BAYER CROPSCIENCE SA (FR) | 2009-07-14 | — | — | US | disclosed |
| US-20080146616-A1 | Indoles Useful in the Treatment of Inflammation | BIOLIPOX AB (SE) | 2008-06-19 | — | — | US | disclosed |
| US-6998489-B2 | Methods of making indazoles | ALCON, INC. (CH) | 2006-02-14 | — | — | US | disclosed |
| EP-1392659-A4 | METHODS OF MAKING INDAZOLES | ALCON INC (CH) | 2004-10-20 | — | — | EP | disclosed |
| US-20040142998-A1 | Methods of making indazoles | ALCON, INC. (CH) | 2004-07-22 | — | — | US | disclosed |
| EP-1392659-A1 | METHODS OF MAKING INDAZOLES | Alcon, Inc. (CH) | 2004-03-03 | — | — | EP | disclosed |
| WO-2002098862-A1 | METHODS OF MAKING INDAZOLES | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |
| WO-2002098861-A1 | METHODS OF MAKING 1-(2-AMINOPROPYL)-6-HYDROXYINDAZOLE | ALCON, INC. (CH) | 2002-12-12 | — | — | WO | disclosed |
| EP-0343574-B1 | 4(1H)-quinolone derivatives | KIRIN BREWERY (JP) | 1994-07-27 | — | — | EP | disclosed |
| US-5081121-A | Cardiotonic agents | KIRIN BEER KABUSHIKI KAISHA (JP) | 1992-01-14 | — | — | US | disclosed |
| US-4997840-A | Quinolone sulphonates having antihypertensive activity | THE BOOTS COMPANY, PLC (GB) | 1991-03-05 | — | — | US | disclosed |
| EP-0343574-A1 | 4(1H)-quinolone derivatives | KIRIN BEER KABUSHIKI KAISHA (JP) | 1989-11-29 | — | — | EP | disclosed |
| EP-0330340-A1 | Therapeutic agents | The Boots Company PLC (GB) | 1989-08-30 | — | — | EP | disclosed |
| WO-1989007593-A1 | THERAPEUTIC AGENTS | THE BOOTS COMPANY PLC (GB) | 1989-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040142998-A1 | Methods of making indazoles | NAT1, CYP3A5, ALDH3A1 | JAK2 3197/4885JAK1 2140/4885FABP4 3859/4885 |
| US-20080146616-A1 | Indoles Useful in the Treatment of Inflammation | IDO1, PTGS1, PTGER1 | JAK2 349/4885JAK1 824/4885FABP4 1807/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.