Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AR | P10275 | 9/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.42 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 9/20 | 0.41 |
| ▸ | TUBB | P07437 | 9/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 9/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 9/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 9/20 | 0.41 |
| ▸ | TUBB4B | P68371 | 9/20 | 0.41 |
| ▸ | TUBB3 | Q13509 | 9/20 | 0.41 |
| ▸ | TUBB2A | Q13885 | 9/20 | 0.41 |
| ▸ | TUBB8 | Q3ZCM7 | 9/20 | 0.41 |
| ▸ | TUBA3E | Q6PEY2 | 9/20 | 0.41 |
| ▸ | TUBA1A | Q71U36 | 9/20 | 0.41 |
| ▸ | TUBA1C | Q9BQE3 | 9/20 | 0.41 |
| ▸ | TUBB6 | Q9BUF5 | 9/20 | 0.41 |
| ▸ | TUBB2B | Q9BVA1 | 9/20 | 0.41 |
| ▸ | TUBB1 | Q9H4B7 | 9/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6087590 | 0.79 | MAOA (0.57) | IMPDH2IMPDH1TUBB4ATUBBTUBA3C | |
| SCHEMBL6087921 | 0.77 | POLB (0.55) | IMPDH2IMPDH1SLC6A4 | |
| Ether SCHEMBL6087189 | 0.76 | PLA2G1B (0.47) | IMPDH2IMPDH1TUBB4ATUBBTUBA3C | |
| SCHEMBL5857256 | 0.75 | PLA2G1B (0.66) | AR | |
| SCHEMBL1778261 | 0.74 | GPR84 (0.57) | IMPDH2IMPDH1 | |
| SCHEMBL6090445 | 0.73 | TUBB4A (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL6087031 | 0.73 | IMPDH2 (0.46) | ARIMPDH2IMPDH1SLC6A4 | |
| SCHEMBL7859196 | 0.72 | CA2 (0.52) | AR | |
| SCHEMBL30832957 | 0.72 | CA2 (0.52) | AR | |
| SCHEMBL12680483 | 0.70 | AR (0.48) | ARIMPDH2IMPDH1TUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7125906-B2 | Indole derivatives having anti-angiogenetic activity | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | claimed |
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | claimed |
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | claimed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | claimed |
| US-7125906-B2 | Indole derivatives having anti-angiogenetic activity | ASTRAZENECA AB (SE) | 2006-10-24 | — | — | US | disclosed |
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | US | disclosed |
| EP-1515716-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | Astrazeneca AB (SE) | 2005-03-23 | — | — | EP | disclosed |
| WO-2003082271-A2 | INDOLE DERIVATIVES HAVING ANTI-ANGIOGENETIC ACTIVITY | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050159474-A1 | Angiogenesis inhibitors for cardiovascular disorders, neovascularization | FLT1, FLT4, VEGFA | AR 3468/4885IMPDH2 3719/4885IMPDH1 2530/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.