Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.36 |
| ▸ | PIN4 | Q9Y237 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.32 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.32 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4466913 | 0.86 | CYP11B1 (0.44) | BRD4PIN1PIN4IDO1CYP1A2 | |
| SCHEMBL4460191 | 0.83 | ALDH1A1 (0.38) | BRD4PIN1PIN4IDO1MAPT | |
| SCHEMBL4473837 | 0.80 | CYP11B1 (0.42) | BRD4IDO1CYP11B1CYP11B2PPARG | |
| SCHEMBL4240397 | 0.77 | SCN9A (0.33) | KCNH2SCN5ASCN9A | |
| SCHEMBL27528495 | 0.74 | CYP11B1 (0.43) | BRD4PIN1PIN4IDO1CYP11B1 | |
| SCHEMBL4479204 | 0.73 | CYP11B1 (0.47) | BRD4IDO1CYP11B1CYP11B2PPARG | |
| SCHEMBL6231541 | 0.71 | PIN1 (0.41) | BRD4LMNAPIN1PIN4IDO1 | |
| SCHEMBL6233172 | 0.70 | PIN1 (0.38) | BRD4LMNAPIN1PIN4IDO1 | |
| SCHEMBL6236384 | 0.70 | ALDH1A1 (0.43) | BRD4PIN1PIN4CYP11B1CYP11B2 | |
| SCHEMBL6234016 | 0.70 | TDP2 (0.42) | LMNAPIN1PIN4IDO1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7078428-B2 | Isoindolone derivatives, preparation process and intermediates of this process, their use as medicaments, and pharmaceutical compositions comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-07-18 | — | — | US | disclosed |