Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.67 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | SLC26A4 | O43511 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | MAOB | P27338 | 3/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.51 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.51 |
| ▸ | GCK | P35557 | 1/20 | 0.51 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.46 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.46 |
| ▸ | FABP4 | P15090 | 1/20 | 0.46 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.45 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088674 | 0.89 | SLC26A4 (0.63) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6088567 | 0.89 | NR4A2 (0.67) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6090155 | 0.87 | NR4A2 (0.57) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL4450809 | 0.86 | NR4A2 (0.58) | NR4A2SLC26A4MEN1KMT2AMAOB | |
| SCHEMBL6088680 | 0.85 | NR4A2 (0.62) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6088483 | 0.84 | SLC26A4 (0.52) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6090532 | 0.84 | SLC26A4 (0.51) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL4451992 | 0.83 | SLC26A4 (0.53) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6090535 | 0.83 | NPC1 (0.55) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6087956 | 0.82 | PTGER4 (0.55) | NR4A2SLC26A4MAOBFFAR1FFAR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |