Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | HTR6 | P50406 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | UBE2N | P61088 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.55 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.55 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30689018 | 1.00 | MEN1 (0.64) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL27958054 | 0.88 | MEN1 (0.83) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL13302218 | 0.84 | ALOX5 (0.68) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL949348 | 0.83 | LMNA (0.82) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL12748306 | 0.83 | AKR1C3 (0.78) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL29414776 | 0.83 | AKR1C3 (0.78) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL22638205 | 0.82 | ALOX5 (0.65) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL30689046 | 0.82 | ALOX5 (0.65) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL12908807 | 0.81 | HTR6 (0.62) | MEN1KMT2AALOX5PTGS2HTR6 | |
| SCHEMBL8074122 | 0.80 | ALOX5 (0.58) | MEN1KMT2AALOX5PTGS2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | ELI LILLY AND COMPANY (US) | 2006-10-19 | — | — | US | disclosed |
| EP-1597254-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | Eli Lilly and Company (US) | 2005-11-23 | — | — | EP | disclosed |
| WO-2004067529-A1 | INDOLE-DERIVATIVE MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060235222-A1 | Indole-derivative modulators of steroid hormone nuclear receptors | NR3C2, NR5A1, MC2R | MEN1 3034/4885KMT2A 3358/4885ALOX5 806/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.