Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.54 |
| ▸ | RXRB | P28702 | 2/20 | 0.54 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.53 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.47 |
| ▸ | RXRG | P48443 | 1/20 | 0.47 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BCL2 | P10415 | 1/20 | 0.44 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088371 | 0.88 | RXRA (0.46) | RXRARXRBMRGPRX4NPC1RAB9A | |
| SCHEMBL6088680 | 0.88 | NR4A2 (0.62) | RXRARXRBMRGPRX4NR4A2RXRG | |
| SCHEMBL4450809 | 0.87 | NR4A2 (0.58) | MRGPRX4NR4A2SLC26A4KDM4ESMN1; SMN2 | |
| SCHEMBL6092100 | 0.86 | RXRA (0.51) | RXRARXRBMRGPRX4NR4A2RXRG | |
| SCHEMBL6087956 | 0.85 | PTGER4 (0.55) | MRGPRX4NR4A2SLC26A4BCL2MAOB | |
| SCHEMBL6087927 | 0.84 | MRGPRX4 (0.53) | MRGPRX4NR4A2SLC26A4NPC1RAB9A | |
| SCHEMBL6091321 | 0.83 | NR4A2 (0.66) | RXRARXRBMRGPRX4NR4A2RXRG | |
| SCHEMBL6088674 | 0.82 | SLC26A4 (0.63) | NR4A2SLC26A4NPC1POLBRAB9A | |
| SCHEMBL6087987 | 0.82 | SLC26A4 (0.46) | MRGPRX4NR4A2SLC26A4NPC1POLB | |
| SCHEMBL6089332 | 0.80 | NR4A2 (0.67) | MRGPRX4NR4A2SLC26A4NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |