Acetic Acid — predicted protein targets

Known targets — ChEMBL curated mechanism

ADRA2A ADRA2B ADRA2C ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CALCR CHRNA3 CHRNB4 ESR1 ESR2 GHSR GNRHR GSC1 HSPA8 MALT1 MC1R MC4R NOS1 NOS2 NOS3 OPRK1 OXTR RAMP1 RAMP2 RAMP3 SCN5A SSTR1 SSTR2 SSTR3 SSTR4 SSTR5 dacA dacB dacC folP ftsI mrcA mrcB mrdA rplA rplB rplC rplD rplE rplF rplJ rplK rplL rplM rplN rplO rplP rplQ rplR rplS rplT rplU rplV rplW rplX rplY rpmA rpmB rpmC rpmD rpmE rpmF rpmG rpmH rpmI rpmJ rpsA rpsB rpsC rpsD rpsE rpsF rpsG rpsH rpsI rpsJ rpsK rpsL rpsM rpsN rpsO rpsP rpsQ rpsR rpsS rpsT rpsU ykgM ykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

	gene	UniProt	supporting neighbours	confidence
▸	FDPS	P14324	4/20	0.43

▸	SMN1; SMN2	Q16637	2/20	0.40

▸	MAPK1	P28482	2/20	0.40

▸	NPC1	O15118	3/20	0.40

▸	RAB9A	P51151	3/20	0.40

▸	HTT	P42858	1/20	0.40

▸	ATM	Q13315	1/20	0.40

▸	L3MBTL1	Q9Y468	4/20	0.37

▸	MAPT	P10636	3/20	0.37

▸	KIF11	P52732	4/20	0.36

▸	CYP1A2	P05177	2/20	0.36

▸	CYP2C19	P33261	2/20	0.36

▸	KDM4E	B2RXH2	2/20	0.36

▸	CYP2C9	P11712	1/20	0.36

▸	NPSR1	Q6W5P4	1/20	0.36

▸	KMT2A	Q03164	1/20	0.36

▸	CYP3A4	P08684	1/20	0.36

▸	CYP2D6	P10635	1/20	0.36

▸	TSHR	P16473	1/20	0.36

▸	HSD17B10	Q99714	1/20	0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Acetic Acid SCHEMBL6092901	0.77	FDPS (0.43)	FDPSSMN1; SMN2NPC1RAB9AMAPT
SCHEMBL4953727	0.75	FDPS (0.58)	FDPSSMN1; SMN2MAPK1NPC1RAB9A
SCHEMBL5673107	0.74	FDPS (0.45)	FDPSSMN1; SMN2NPC1RAB9AMAPT
SCHEMBL6524319	0.67	FDPS (0.42)	FDPSSMN1; SMN2MAPK1NPC1RAB9A
SCHEMBL4195984	0.66	L3MBTL1 (0.53)	FDPSSMN1; SMN2MAPK1NPC1RAB9A
SCHEMBL4195980	0.66	L3MBTL1 (0.53)	FDPSSMN1; SMN2MAPK1NPC1RAB9A
SCHEMBL13794372	0.66	FDPS (0.60)	FDPSSMN1; SMN2MAPK1NPC1RAB9A
SCHEMBL13957327	0.66	CYP1A2 (0.50)	CYP1A2HSD17B10
Hydrochloric Acid SCHEMBL7082607	0.66	NOS2 (0.43)	KIF11
Hydrochloric Acid SCHEMBL7083750	0.66	NOS2 (0.43)	KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-20060270714-A1	Novel n-substituted 2-aminopyridine derivatives	ASTRAZENECA AB (SE)	2006-11-30	—	—	US	disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

Patent	Title	Text reads most about	Predicted target · text-rank
US-20060270714-A1	Novel n-substituted 2-aminopyridine derivatives	NOS1, NOS2, NOS3	FDPS 878/4885SMN1; SMN2 1200/4885MAPK1 1506/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.