Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | SLC26A4 | O43511 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGAV | P06756 | 1/20 | 0.39 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6091423 | 0.92 | SLC26A4 (0.43) | FFAR1SLC26A4KMT2AMEN1CYSLTR2 | |
| SCHEMBL6091090 | 0.91 | PPARG (0.42) | PPARGFFAR1CYP3A4RXRAITGB3 | |
| SCHEMBL6090266 | 0.83 | SLC26A4 (0.46) | PPARGSLC26A4ITGB3ITGB1ITGAV | |
| SCHEMBL6092100 | 0.82 | RXRA (0.51) | RXRASLC26A4KMT2AMEN1PTGER4 | |
| SCHEMBL6088853 | 0.82 | CYSLTR1 (0.43) | KMT2AMEN1CYSLTR1NPC1TSHR | |
| SCHEMBL6090336 | 0.80 | CYSLTR1 (0.58) | CYSLTR2CYSLTR1 | |
| SCHEMBL6088972 | 0.78 | PPARG (0.49) | PPARGCYP3A4RXRAKMT2AMEN1 | |
| SCHEMBL6089164 | 0.77 | PTGER4 (0.47) | FFAR1SLC26A4CYSLTR1PTGER4NPC1 | |
| SCHEMBL4450809 | 0.76 | NR4A2 (0.58) | SLC26A4KMT2AMEN1PTGER4ALDH1A1 | |
| SCHEMBL6088674 | 0.76 | SLC26A4 (0.63) | FFAR1SLC26A4KMT2AMEN1PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |
| EP-1177176-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | Aventis Pharma Deutschland GmbH (DE) | 2002-02-06 | — | — | EP | disclosed |
| WO-2000064876-A1 | TRI-ARYL ACID DERIVATIVES AS PPAR RECEPTOR LIGANDS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-02 | — | — | WO | disclosed |