Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 5/20 | 0.46 |
| ▸ | SLC26A4 | O43511 | 2/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.44 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6088508 | 0.88 | CYSLTR1 (0.44) | NR4A2NPC1RAB9AMRGPRX4CYSLTR1 | |
| SCHEMBL6088808 | 0.84 | SLC26A4 (0.46) | NR4A2NPC1RAB9AMRGPRX4SLC26A4 | |
| SCHEMBL6090629 | 0.84 | CYSLTR1 (0.54) | NR4A2MRGPRX4NR4A1NR4A3CYSLTR1 | |
| SCHEMBL6089761 | 0.83 | GPR132 (0.49) | NR4A2NPC1RAB9ASLC26A4PPARG | |
| SCHEMBL5725146 | 0.82 | CYSLTR1 (0.67) | CYSLTR1GPBAR1CYSLTR2 | |
| SCHEMBL6089332 | 0.82 | NR4A2 (0.67) | NR4A2NPC1RAB9AMRGPRX4SLC26A4 | |
| SCHEMBL6088674 | 0.81 | SLC26A4 (0.63) | NR4A2NPC1RAB9ASLC26A4MEN1 | |
| SCHEMBL6088614 | 0.81 | CYSLTR1 (0.50) | NR4A2NPC1RAB9ASLC26A4CYSLTR1 | |
| SCHEMBL6088680 | 0.80 | NR4A2 (0.62) | NR4A2NPC1RAB9AMRGPRX4SLC26A4 | |
| SCHEMBL6088483 | 0.79 | SLC26A4 (0.52) | NR4A2NPC1RAB9AMRGPRX4SLC26A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7005440-B1 | Therapeutic uses of tri-aryl acid derivatives | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2006-02-28 | — | — | US | disclosed |