Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | C5 | P01031 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4371236 | 0.89 | ROCK2 (0.47) | HSD17B10ROCK2ROCK1ALDH1A1ADORA2B | |
| SCHEMBL6091959 | 0.86 | LMNA (0.53) | HSD17B10ALDH1A1TSHRRAB9AMAPT | |
| SCHEMBL6094823 | 0.86 | LMNA (0.53) | HSD17B10ALDH1A1TSHRRAB9AMAPT | |
| SCHEMBL20707804 | 0.83 | ADORA2A (0.46) | HSD17B10ALDH1A1ADORA2ARAB9AMAPT | |
| SCHEMBL4365319 | 0.82 | METAP1 (0.48) | HSD17B10ROCK2ROCK1MTORTSHR | |
| SCHEMBL4367957 | 0.82 | METAP1 (0.48) | HSD17B10ROCK2ROCK1MTORTSHR | |
| SCHEMBL6094016 | 0.82 | ROCK2 (0.52) | ROCK2ROCK1ADORA2BADORA1RAB9A | |
| SCHEMBL4372959 | 0.80 | KDM4E (0.44) | HSD17B10ROCK2ALDH1A1MAPK1RAB9A | |
| SCHEMBL6096686 | 0.78 | EPHX1 (0.48) | HSD17B10ALDH1A1RAB9AMAPTKDM4E | |
| Trifluoroacetic Acid SCHEMBL4376103 | 0.78 | METAP1 (0.44) | HSD17B10ROCK2ROCK1MTORTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060036098-A1 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators | MERCK SHARP & DOHME CORP. | 2006-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060036098-A1 | Carbonylamino-benzimidazole derivatives as androgen receptor modulators | AR, SHBG, BRCA1 | HSD17B10 1275/4885ROCK2 1265/4885ROCK1 609/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.