Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP7 | P09237 | 3/20 | 0.38 |
| ▸ | MMP12 | P39900 | 3/20 | 0.38 |
| ▸ | MMP13 | P45452 | 3/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | LARS1 | Q9P2J5 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6095331 | 0.84 | LARS1 (0.47) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL8778753 | 0.83 | PSIP1 (0.50) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL3917298 | 0.77 | SMN1; SMN2 (0.50) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL27816013 | 0.74 | PSIP1 (0.48) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL2446838 | 0.74 | PSIP1 (0.52) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL3328706 | 0.73 | TSHR (0.48) | PSIP1SMN1; SMN2MMP1MMP13LMNA | |
| SCHEMBL17055249 | 0.73 | MMP1 (0.44) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL27948845 | 0.72 | HPGD (0.51) | PSIP1SMN1; SMN2MMP1MMP7MMP12 | |
| SCHEMBL27430447 | 0.72 | TSHR (0.43) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 | |
| SCHEMBL4432536 | 0.72 | TSHR (0.43) | PSIP1SMN1; SMN2HSD11B1MMP1MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | PSIP1 1776/4885SMN1; SMN2 1794/4885HSD11B1 767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.