Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSIP1 | O75475 | 1/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.45 |
| ▸ | MMP13 | P45452 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MMP1 | P03956 | 2/20 | 0.37 |
| ▸ | MMP2 | P08253 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6094849 | 0.84 | PSIP1 (0.48) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL2446758 | 0.78 | PSIP1 (0.59) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL28670237 | 0.76 | CYP2C19 (0.55) | ALDH1A1TSHRCYP3A4CYP2C19LMNA | |
| SCHEMBL2446368 | 0.75 | PSIP1 (0.60) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL17542323 | 0.75 | ALDH1A1 (0.38) | ALDH1A1NPC1RAB9AKMT2AMEN1 | |
| SCHEMBL7296389 | 0.74 | PSIP1 (0.58) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL1540327 | 0.72 | PSIP1 (0.56) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL1540325 | 0.72 | PSIP1 (0.56) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL19248406 | 0.72 | PSIP1 (0.56) | PSIP1HSD11B1MMP13ALDH1A1HTT | |
| SCHEMBL1527680 | 0.72 | HSD11B1 (0.56) | PSIP1HSD11B1MMP13ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7101892-B2 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. | 2006-09-05 | — | — | US | disclosed |
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | MERCK SHARP & DOHME LTD. (GB) | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040229864-A1 | Sulfone derivatives as 5-HT7 receptor ligands | HTR7, HTR2C, HTR1A | PSIP1 1776/4885HSD11B1 767/4885MMP13 4669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.