Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13736583 | 0.82 | CALM1 (0.64) | MAOBCALM1MAPTTSHRKDM4E | |
| SCHEMBL30514387 | 0.81 | MAOB (0.70) | MAOBCHRNB4CHRNA3ESR1ESR2 | |
| SCHEMBL119396 | 0.81 | MAOB (0.70) | MAOBCHRNB4CHRNA3ESR1ESR2 | |
| SCHEMBL6036396 | 0.81 | BACE1 (0.47) | MAOBBACE1APPESR1ESR2 | |
| SCHEMBL12587297 | 0.81 | BACE1 (0.43) | MAOBBACE1ESR1ESR2MAPT | |
| SCHEMBL10921912 | 0.79 | KDM4E (0.54) | MAOBCALM1CHRNB4CHRNA3KDM4E | |
| SCHEMBL3721034 | 0.79 | HSD17B10 (0.43) | MAOBBACE1MAPTCYP3A4TSHR | |
| SCHEMBL6097944 | 0.79 | BACE1 (0.43) | MAOBBACE1MAPTCYP3A4KDM4E | |
| SCHEMBL31464131 | 0.79 | BACE1 (0.43) | MAOBBACE1ESR1ESR2MEN1 | |
| SCHEMBL27140275 | 0.79 | BACE1 (0.43) | MAOBBACE1ESR1ESR2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022732-B2 | 6-substituted 2,3-dihydro-1,4-benzodioxine, 2-position substituted with carboxy, or (C1 C6)alkoxycarbonyl; diabetes, obesity; 6-[2-(R)-[2-(S)-hydroxy-3-(4-hydroxy-3-methanesulfonamido-phenoxy)propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid; B3 andrenergic receptor agonist | NISSHIN PHARMA INC. (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040235921-A1 | Propanolamine derivative having 1, 4-Benzodioxane ring | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1426370-A1 | PROPANOLAMINE DERIVATIVE HAVING 1,4 BENZODIOXANE RING | Nisshin Pharma Inc. (JP) | 2004-06-09 | — | — | EP | disclosed |
| US-5849732-A | Phenol compound having antioxidative activity and the process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0790240-A1 | Phenol-derivatives having pharmaceutical activity and process for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1997-08-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235921-A1 | Propanolamine derivative having 1, 4-Benzodioxane ring | ADRA1D, ADRA1A, ADRB1 | MAOB 1092/4885BACE1 2566/4885CALM1 2338/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.