Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8673547 | 0.81 | HSD17B10 (0.61) | USP2NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL6099115 | 0.79 | MAOB (0.53) | BACE1GAAKDM4EMEN1MAPT | |
| SCHEMBL12587297 | 0.79 | BACE1 (0.43) | BACE1MEN1MAPTKMT2AMAOB | |
| SCHEMBL9423697 | 0.79 | ALDH1A1 (0.62) | USP2NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL926801 | 0.78 | ALDH1A1 (0.59) | HSD17B10ALDH1A1GAAHTTMEN1 | |
| SCHEMBL7281787 | 0.78 | ALDH1A1 (0.63) | BACE1USP2RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL30116198 | 0.78 | SLC6A2 (0.41) | USP2NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL20597617 | 0.78 | SLC6A2 (0.41) | USP2NPC1RAB9ASMN1; SMN2HSD17B10 | |
| SCHEMBL31464131 | 0.78 | BACE1 (0.43) | BACE1RAB9AALDH1A1HTTMEN1 | |
| SCHEMBL3721034 | 0.78 | HSD17B10 (0.43) | BACE1HSD17B10MAPTMAOBTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7022732-B2 | 6-substituted 2,3-dihydro-1,4-benzodioxine, 2-position substituted with carboxy, or (C1 C6)alkoxycarbonyl; diabetes, obesity; 6-[2-(R)-[2-(S)-hydroxy-3-(4-hydroxy-3-methanesulfonamido-phenoxy)propylamino]propyl]-2,3-dihydro-1,4-benzodioxine-2-(R)-carboxylic acid; B3 andrenergic receptor agonist | NISSHIN PHARMA INC. (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040235921-A1 | Propanolamine derivative having 1, 4-Benzodioxane ring | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 2004-11-25 | — | — | US | disclosed |
| EP-1426370-A1 | PROPANOLAMINE DERIVATIVE HAVING 1,4 BENZODIOXANE RING | Nisshin Pharma Inc. (JP) | 2004-06-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040235921-A1 | Propanolamine derivative having 1, 4-Benzodioxane ring | ADRA1D, ADRA1A, ADRB1 | BACE1 2566/4885USP2 2783/4885NPC1 268/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.