Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 10/20 | 0.44 |
| ▸ | HTR7 | P34969 | 10/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.41 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | FEN1 | P39748 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4638964 | 0.91 | MEN1 (0.45) | MEN1KMT2AHTR1AHTR7PSEN1 | |
| SCHEMBL4617481 | 0.85 | KDM4E (0.46) | KMT2AHTR1AHTR7DRD2HTR6 | |
| SCHEMBL6102384 | 0.82 | HTR1A (0.42) | KMT2AHTR1AHTR7DRD2HTR6 | |
| SCHEMBL4638533 | 0.78 | PSEN1 (0.46) | MEN1KMT2AHTR1AHTR7PSEN1 | |
| SCHEMBL4619179 | 0.78 | ALDH1A1 (0.47) | MEN1KMT2AHTR1AHTR7 | |
| SCHEMBL4617920 | 0.75 | HTR1A (0.45) | KMT2AHTR1AHTR7DRD2HTR6 | |
| SCHEMBL4782205 | 0.75 | CA1 (0.50) | MEN1KMT2AHTR1AHTR7PSEN1 | |
| SCHEMBL4736402 | 0.75 | HTR1A (0.38) | MEN1KMT2AHTR1AHTR7PSEN1 | |
| SCHEMBL6101380 | 0.75 | HTR1A (0.41) | HTR1AHTR7DRD2HTR6HTR2A | |
| SCHEMBL4617601 | 0.74 | HTR1A (0.44) | KMT2AHTR1AHTR7DRD2HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | claimed |
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | WYETH (US) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276464-A1 | Diarylsulfone sulfonamides and use thereof | SFRP1, SOS1, FZD7 | MEN1 886/4885KMT2A 3832/4885HTR1A 3561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.