Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 17/20 | 0.48 |
| ▸ | DRD2 | P14416 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | HTR1D | P28221 | 1/20 | 0.32 |
| ▸ | HTR1B | P28222 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6834659 | 1.00 | HTR1A (0.48) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL5444167 | 0.83 | MEN1 (0.38) | HTR1ADRD2MEN1TSHRKMT2A | |
| SCHEMBL4821524 | 0.82 | TSHR (0.35) | HTR1AMEN1TSHRKMT2ALMNA | |
| SCHEMBL4363794 | 0.77 | HTR1A (0.55) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4998334 | 0.77 | HTR1A (0.55) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4375168 | 0.77 | HTR1A (0.55) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL6107718 | 0.77 | DRD2 (0.43) | HTR1ADRD2DRD4DRD3MEN1 | |
| SCHEMBL4375219 | 0.76 | HTR1A (0.47) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL4372252 | 0.76 | HTR1A (0.47) | HTR1ADRD2CYP3A4CYP2C8DRD4 | |
| SCHEMBL13927903 | 0.76 | HTR1A (0.56) | HTR1ADRD2CYP3A4CYP2C8DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060293301-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | WYETH (US) | 2006-12-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060293301-A1 | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans | CRH, HTR5A, DBH | HTR1A 121/4885DRD2 20/4885CYP3A4 285/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.