Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6111192 | 0.80 | ALDH1A1 (0.52) | KDM4EHPGDPPARGNCOA2NCOA1 | |
| SCHEMBL5809944 | 0.78 | PDE4B (0.51) | KDM4EHPGDPPARGNCOA2NCOA1 | |
| SCHEMBL6109551 | 0.72 | KDM4E (0.51) | KDM4EHPGDNPSR1LMNASMN1; SMN2 | |
| SCHEMBL18015638 | 0.69 | PBRM1 (0.54) | KDM4EHPGDLMNAL3MBTL1NPC1 | |
| SCHEMBL6110675 | 0.69 | CRHR1 (0.47) | KDM4ENPSR1L3MBTL1NPC1RAB9A | |
| SCHEMBL6112336 | 0.67 | ADORA2A (0.50) | KDM4EHPGDNPSR1LMNATP53 | |
| SCHEMBL21048258 | 0.66 | KDM4E (0.34) | KDM4EHPGDPPARGNPSR1SMN1; SMN2 | |
| SCHEMBL1321790 | 0.65 | NPSR1 (0.37) | KDM4EHPGDPPARGNCOA2NCOA1 | |
| SCHEMBL22030567 | 0.64 | PBRM1 (0.48) | KDM4EHPGDLMNAL3MBTL1NPC1 | |
| SCHEMBL21076006 | 0.63 | KDM4E (0.33) | KDM4EHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006010568-A2 | SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND USE THEREOF AS INHIBITORS OF TNF-ALPHA RELEASE | CURACYTE DISCOVERY GMBH (DE) | 2006-02-02 | — | — | WO | disclosed |