Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.66 |
| ▸ | CA9 | Q16790 | 4/20 | 0.66 |
| ▸ | CA1 | P00915 | 2/20 | 0.66 |
| ▸ | CA2 | P00918 | 2/20 | 0.66 |
| ▸ | CA4 | P22748 | 2/20 | 0.66 |
| ▸ | CA5A | P35218 | 2/20 | 0.66 |
| ▸ | CA7 | P43166 | 2/20 | 0.66 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.66 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.66 |
| ▸ | CA3 | P07451 | 1/20 | 0.66 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL757472 | 0.81 | NPC1 (0.49) | CA12CA9CA1CA2CA4 | |
| SCHEMBL28878363 | 0.80 | CA12 (1.00) | CA12CA9CA1CA2CA4 | |
| SCHEMBL31290721 | 0.77 | ALDH1A1 (0.68) | CA12CA9CA1MAOBNPC1 | |
| SCHEMBL757926 | 0.77 | ALDH1A1 (0.68) | CA12CA9CA1MAOBNPC1 | |
| SCHEMBL2808427 | 0.77 | CA12 (0.59) | CA12CA9CA1CA2CA4 | |
| SCHEMBL724134 | 0.77 | ALDH1A1 (0.68) | CA12CA9CA1CA2CA4 | |
| SCHEMBL14424517 | 0.77 | CA12 (0.61) | CA12CA9CA1MAOBNPC1 | |
| SCHEMBL14341910 | 0.76 | LCK (0.71) | NPC1MEN1KMT2ARAB9ATDP1 | |
| SCHEMBL10822063 | 0.76 | ALDH1A1 (0.68) | CA12CA9CA1CA2CA4 | |
| SCHEMBL761091 | 0.76 | NPC1 (0.47) | CA12CA9CA1CA2CA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295053-B1 | Novel 2H-chromen-2-one-3-carboxamides for medical uses | INST MATERIA MEDICA CAMS (CN) | 2016-10-19 | — | — | EP | disclosed |
| EP-2295053-B1 | Novel 2H-chromen-2-one-3-carboxamides for medical uses | INST MATERIA MEDICA CAMS (CN) | 2016-10-19 | — | — | EP | disclosed |
| US-8338401-B2 | Coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-12-25 | — | — | US | disclosed |
| US-8338401-B2 | Coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-12-25 | — | — | US | disclosed |
| US-8338401-B2 | Coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-12-25 | — | — | US | disclosed |
| CN-100488504-C | Coumarin amide derivative, its preparation method, its medicinal composition and application | INST MATERIA MEDICA CAMS (CN) | 2009-05-20 | — | — | CN | disclosed |
| US-20060148834-A1 | Novel coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2006-07-06 | — | — | US | disclosed |
| EP-1570846-A1 | THE NOVEL COUMARIN-AMIDE DERIVATIVES AND ITS PREPARATION, SAID DRUG COMPOSITION AND ITS USE | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148834-A1 | Novel coumarin-amide derivatives and its preparation, said drug composition and its use | INSR, GLS, INSRR | CA12 3153/4885CA9 863/4885CA1 3149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.