SCHEMBL6123646

SCHEMBL6123646

O=Cc1c(C(=O)O)nn(-c2ccccc2)c1Cl

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.49
LMNA P02545 4/20 0.49
MAPT P10636 4/20 0.49
NPSR1 Q6W5P4 2/20 0.49
RECQL P46063 1/20 0.49
SMN1; SMN2 Q16637 5/20 0.48
MAPK1 P28482 3/20 0.47
RAB9A P51151 3/20 0.46
GAA P10253 3/20 0.46
NPC1 O15118 2/20 0.45
TP53 P04637 1/20 0.45
KDM4E B2RXH2 2/20 0.45
HTT P42858 1/20 0.43
CYP1A2 P05177 1/20 0.43
HIF1A Q16665 1/20 0.43
HPGD P15428 2/20 0.42
TSHR P16473 1/20 0.42
MEN1 O00255 1/20 0.42
NFKB1 P19838 1/20 0.42
GFER P55789 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15331640 0.84 GAA (0.63) ALDH1A1LMNAMAPTNPSR1RECQL
SCHEMBL6515355 0.84 ALDH1A1 (0.46) ALDH1A1LMNAMAPTNPSR1SMN1; SMN2
SCHEMBL11567527 0.83 MAPK1 (0.48) ALDH1A1LMNAMAPTSMN1; SMN2MAPK1
SCHEMBL2679077 0.81 NPSR1 (0.39) ALDH1A1MAPTNPSR1SMN1; SMN2RAB9A
SCHEMBL6123645 0.81 ALDH1A1 (0.57) ALDH1A1MAPTSMN1; SMN2RAB9AGAA
SCHEMBL15332289 0.78 SMN1; SMN2 (0.46) ALDH1A1LMNAMAPTNPSR1RECQL
SCHEMBL15332292 0.78 SMN1; SMN2 (0.46) ALDH1A1LMNAMAPTNPSR1RECQL
SCHEMBL1267498 0.78 SMN1; SMN2 (0.66) ALDH1A1LMNAMAPTNPSR1RECQL
SCHEMBL11728399 0.76 SMN1; SMN2 (0.50) ALDH1A1LMNAMAPTNPSR1RECQL
SCHEMBL5768692 0.76 LMNA (0.50) ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220340893-A1 BI-FUNCTIONAL COMPLEXES AND METHODS FOR MAKING AND USING SUCH COMPLEXES NUEVOLUTION A/S (DK) 2022-10-27 US disclosed
US-8173680-B2 Cannabinoid receptor modulators 7TM PHARMA A/S (DK) 2012-05-08 US disclosed
US-20100292273-A1 Cannabinoid Receptor Modulators 7TM PHARMA A/S (DK) 2010-11-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100292273-A1 Cannabinoid Receptor Modulators CNR1, CNR2, CBR1 ALDH1A1 1244/4885LMNA 2118/4885MAPT 4711/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.