Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL692641 | 0.83 | POLB (0.57) | POLBSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL8271284 | 0.83 | POLB (0.57) | POLBSMN1; SMN2HTTALDH1A1GAA | |
| Ammonia Solution, Strong SCHEMBL13280491 | 0.82 | POLB (0.55) | POLBSMN1; SMN2HTTALDH1A1GAA | |
| SCHEMBL13472137 | 0.78 | POLB (0.46) | POLBSMN1; SMN2HTTKMT2AGAA | |
| SCHEMBL26660473 | 0.77 | KMT2A (0.46) | POLBSMN1; SMN2HTTKMT2A | |
| SCHEMBL8292848 | 0.73 | L3MBTL1 (0.51) | NPC1RAB9APOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL8001584 | 0.72 | POLB (0.41) | NPC1RAB9APOLBSMN1; SMN2HTT | |
| SCHEMBL7464776 | 0.72 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2HTTALDH1A1 | |
| SCHEMBL8859113 | 0.70 | ACE (0.41) | POLBALDH1A1KMT2A | |
| SCHEMBL15018763 | 0.70 | ACE (0.41) | POLBALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8575349-B2 | Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575349-B2 | Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-8575349-B2 | Derivatives of 1-alkyl-6-oxo-piperidine-3-carboxylic acids and 1-alkyl-5-oxo-pyrrolidine-3-carboxylic acids and their uses as cooling compounds | INTERNATIONAL FLAVORS & FRAGRANCES INC. (US) | 2013-11-05 | — | — | US | disclosed |
| US-20120129827-A1 | NOVEL DERIVATIVES OF 1-ALKYL-6-OXO-PIPERIDINE-3-CARBOXYLIC ACIDS AND 1-ALKYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDS AND THEIR USES AS COOLING COMPOUNDS | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2012-05-24 | — | — | US | disclosed |
| US-20120129827-A1 | NOVEL DERIVATIVES OF 1-ALKYL-6-OXO-PIPERIDINE-3-CARBOXYLIC ACIDS AND 1-ALKYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDS AND THEIR USES AS COOLING COMPOUNDS | INTERNATIONAL FLAVORS & FRAGRANCES INC. | 2012-05-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120129827-A1 | NOVEL DERIVATIVES OF 1-ALKYL-6-OXO-PIPERIDINE-3-CARBOXYLIC ACIDS AND 1-ALKYL-5-OXO-PYRROLIDINE-3-CARBOXYLIC ACIDS AND THEIR USES AS COOLING COMPOUNDS | CPS1, COX5A, COX5B | NPC1 2968/4885RAB9A 2023/4885POLB 369/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.