Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | AGXT | P21549 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.34 |
| ▸ | FAAH | O00519 | 3/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28055769 | 0.80 | ALDH1A1 (0.41) | IDO1ALDH1A1TSHRMAPK1L3MBTL1 | |
| SCHEMBL11895704 | 0.75 | TSHR (0.48) | IDO1AGXTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL11895703 | 0.75 | TSHR (0.48) | IDO1AGXTALDH1A1TSHRL3MBTL1 | |
| SCHEMBL1614607 | 0.75 | CETP (0.47) | ALDH1A1TSHRMAPK1L3MBTL1EPHX2 | |
| SCHEMBL1614849 | 0.75 | CETP (0.47) | ALDH1A1TSHRMAPK1L3MBTL1EPHX2 | |
| SCHEMBL11895951 | 0.72 | L3MBTL1 (0.51) | IDO1TSHRL3MBTL1EPHX2FAAH | |
| SCHEMBL11895950 | 0.72 | L3MBTL1 (0.51) | IDO1TSHRL3MBTL1EPHX2FAAH | |
| SCHEMBL26226333 | 0.72 | ALDH1A1 (0.56) | ALDH1A1MAPK1L3MBTL1LMNATRPV1 | |
| SCHEMBL1225568 | 0.71 | SIGMAR1 (0.50) | MAPK1L3MBTL1TRPV1 | |
| SCHEMBL1225567 | 0.71 | SIGMAR1 (0.50) | MAPK1L3MBTL1TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1181274-A4 | IMINOCYCLITOL INHIBITORS OF HEXOAMINIDASE AND GLYCOSIDASE | SCRIPPS RESEARCH INST (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1181274-A1 | IMINOCYCLITOL INHIBITORS OF HEXOAMINIDASE AND GLYCOSIDASE | The Scripps Research Institute (US) | 2002-02-27 | — | — | EP | disclosed |
| WO-2000068194-A1 | IMINOCYCLITOL INHIBITORS OF HEXOAMINIDASE AND GLYCOSIDASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2000-11-16 | — | — | WO | disclosed |