SCHEMBL6129795

SCHEMBL6129795

CS(=O)(=O)O.CS(C)(C)c1ccccc1

nearest known ligand 0.59

Known targets — ChEMBL curated mechanism

ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol

The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.59
TSHR P16473 1/20 0.59
CA2 P00918 3/20 0.52
CA1 P00915 2/20 0.52
MMP1 P03956 1/20 0.52
MMP2 P08253 1/20 0.52
MMP9 P14780 1/20 0.52
MMP8 P22894 1/20 0.52
MMP13 P45452 1/20 0.52
HTR6 P50406 2/20 0.50
PSIP1 O75475 1/20 0.48
BCAT1 P54687 1/20 0.47
KEAP1 Q14145 2/20 0.46
ALDH1A1 P00352 3/20 0.46
HSD17B10 Q99714 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
CA12 O43570 1/20 0.46
CA3 P07451 1/20 0.46
CA4 P22748 1/20 0.46
CA6 P23280 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2937203 0.86 HTR6 (0.47) SMN1; SMN2TSHRCA2CA1MMP1
Trifluoromethanesulfonic Acid SCHEMBL27603647 0.84 TSHR (0.48) SMN1; SMN2TSHRCA2CA1MMP1
SCHEMBL2638204 0.84 TSHR (0.84) SMN1; SMN2TSHRCA2CA1MMP1
Fluoride SCHEMBL943941 0.83 HTR6 (0.45) SMN1; SMN2TSHRCA2CA1MMP1
Sulfuric Acid SCHEMBL6731449 0.82 TSHR (0.80) SMN1; SMN2TSHRCA2CA1MMP1
Benzenesulfonamide SCHEMBL30171245 0.80 CA1 (0.76) SMN1; SMN2TSHRCA2CA1ALDH1A1
Benzenesulfonamide SCHEMBL27508743 0.80 CA1 (0.76) SMN1; SMN2TSHRCA2CA1ALDH1A1
Bromide SCHEMBL1067860 0.80 TSHR (0.76) SMN1; SMN2TSHRCA2CA1MMP1
Dimethyl Sulfone SCHEMBL28006518 0.79 TSHR (0.84) SMN1; SMN2TSHRCA2CA1MMP1
SCHEMBL28199063 0.79 TSHR (0.84) SMN1; SMN2TSHRCA2CA1MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1299774-A4 PERFLUOROALKYLSULFONIC ACID COMPOUNDS FOR PHOTORESISTS ARCH SPEC CHEM INC (US) 2005-06-08 EP disclosed
US-6855476-B2 Photoacid generators for use in photoresist compositions ARCH SPECIALTY CHEMICALS, INC. (US) 2005-02-15 US disclosed
EP-1299774-A1 PERFLUOROALKYLSULFONIC ACID COMPOUNDS FOR PHOTORESISTS ARCH SPECIALTY CHEMICALS, INC. (US) 2003-04-09 EP disclosed
US-20020197558-A1 Photoacid generators for use in photoresist compositions ARCH SPECIALTY CHEMICALS, INC. 2002-12-26 US disclosed
WO-2002082185-A1 PERFLUOROALKYLSULFONIC ACID COMPOUNDS FOR PHOTORESISTS ARCH SPECIALTY CHEMICALS, INC. (US) 2002-10-17 WO disclosed