Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Midazolam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 7/20 | 0.61 |
| ▸ | GABRA5 known ✓ | P31644 | 7/20 | 0.61 |
| ▸ | GABRA3 known ✓ | P34903 | 7/20 | 0.61 |
| ▸ | GABRA2 known ✓ | P47869 | 7/20 | 0.61 |
| ▸ | GABRB2 known ✓ | P47870 | 6/20 | 0.61 |
| ▸ | GABRG2 known ✓ | P18507 | 5/20 | 0.61 |
| ▸ | GABRB3 known ✓ | P28472 | 5/20 | 0.61 |
| ▸ | GABRP known ✓ | O00591 | 3/20 | 0.61 |
| ▸ | GABRD known ✓ | O14764 | 3/20 | 0.61 |
| ▸ | GABRB1 known ✓ | P18505 | 3/20 | 0.61 |
| ▸ | GABRA4 known ✓ | P48169 | 3/20 | 0.61 |
| ▸ | GABRE known ✓ | P78334 | 3/20 | 0.61 |
| ▸ | GABRA6 known ✓ | Q16445 | 3/20 | 0.61 |
| ▸ | GABRG1 known ✓ | Q8N1C3 | 3/20 | 0.61 |
| ▸ | GABRG3 known ✓ | Q99928 | 3/20 | 0.61 |
| ▸ | GABRQ known ✓ | Q9UN88 | 3/20 | 0.61 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.63 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.63 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Midazolam SCHEMBL2687953 | 0.90 | OPRK1 (0.57) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Flunitrazepam SCHEMBL8364961 | 0.82 | GABRA1 (0.64) | OPRK1PDE4DGABRA1GABRA5GABRA3 | |
| Alprazolam SCHEMBL3905590 | 0.80 | GABRA1 (0.62) | OPRK1PDE4DGABRA1GABRA5GABRA3 | |
| Midazolam SCHEMBL5783371 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29735381 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29565146 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29357425 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL35061 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| Midazolam SCHEMBL29480459 | 0.80 | OPRK1 (1.00) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 | |
| SCHEMBL7347371 | 0.79 | OPRK1 (0.61) | OPRK1PDE4DCYP3A4SLC22A1ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303280-A4 | ENHANCED BRAIN FUNCTION BY GABA-ERGIC STIMULATION | UNIV UTAH RES FOUND (US) | 2005-09-21 | — | — | EP | claimed |
| EP-1303280-A1 | ENHANCED BRAIN FUNCTION BY GABA-ERGIC STIMULATION | University of Utah Research Foundation (US) | 2003-04-23 | — | — | EP | claimed |
| WO-2002000221-A1 | ENHANCED BRAIN FUNCTION BY GABA-ERGIC STIMULATION | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2002-01-03 | — | — | WO | claimed |