Known targets — ChEMBL curated mechanism
GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQ
The experimentally established mechanism targets of Flurazepam. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 known ✓ | P14867 | 5/20 | 0.64 |
| ▸ | GABRA5 known ✓ | P31644 | 5/20 | 0.64 |
| ▸ | GABRA2 known ✓ | P47869 | 5/20 | 0.64 |
| ▸ | GABRA3 known ✓ | P34903 | 4/20 | 0.64 |
| ▸ | GABRG2 known ✓ | P18507 | 1/20 | 0.64 |
| ▸ | GABRB3 known ✓ | P28472 | 1/20 | 0.64 |
| ▸ | GABRB2 known ✓ | P47870 | 4/20 | 0.53 |
| ▸ | OPRK1 | P41145 | 4/20 | 0.76 |
| ▸ | DRD3 | P35462 | 2/20 | 0.76 |
| ▸ | HTR1A | P08908 | 1/20 | 0.76 |
| ▸ | HTR3A | P46098 | 1/20 | 0.76 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.76 |
| ▸ | GHSR | Q92847 | 1/20 | 0.76 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.64 |
| ▸ | PTAFR | P25105 | 9/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Flurazepam SCHEMBL29793 | 0.87 | OPRK1 (1.00) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL10587083 | 0.87 | OPRK1 (1.00) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL29565153 | 0.87 | OPRK1 (1.00) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL18396062 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL29792 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL30690402 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL5499515 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL29794 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL29368156 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 | |
| Flurazepam SCHEMBL29378257 | 0.86 | OPRK1 (0.98) | OPRK1DRD3HTR1AHTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1303280-A4 | ENHANCED BRAIN FUNCTION BY GABA-ERGIC STIMULATION | UNIV UTAH RES FOUND (US) | 2005-09-21 | — | — | EP | claimed |
| EP-1303280-A1 | ENHANCED BRAIN FUNCTION BY GABA-ERGIC STIMULATION | University of Utah Research Foundation (US) | 2003-04-23 | — | — | EP | claimed |
| WO-2002000221-A1 | ENHANCED BRAIN FUNCTION BY GABA-ERGIC STIMULATION | UNIVERSITY OF UTAH RESEARCH FOUNDATION (US) | 2002-01-03 | — | — | WO | claimed |