Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA4 | P22748 | 1/20 | 0.35 |
| ▸ | CA7 | P43166 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8994708 | 0.78 | KMT2A (0.49) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL8994715 | 0.76 | KMT2A (0.49) | HTTL3MBTL1KMT2AMEN1NPSR1 | |
| SCHEMBL23494962 | 0.74 | KMT2A (0.47) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL7616686 | 0.71 | KMT2A (0.51) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL6130216 | 0.71 | HDAC4 (0.45) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL6130205 | 0.71 | KMT2A (0.48) | HTTL3MBTL1KMT2AMEN1LMNA | |
| SCHEMBL18486442 | 0.71 | KMT2A (0.60) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL14754995 | 0.71 | KMT2A (0.62) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL14259711 | 0.71 | KMT2A (0.60) | HTTL3MBTL1KMT2AMEN1CA2 | |
| SCHEMBL3803849 | 0.71 | HTT (0.51) | HTTL3MBTL1KMT2AMEN1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341797-A4 | ORTHO SUBSTITUTED CHIRAL PHOSPHINES AND PHOSPHINITES AND THEIR USE IN ASYMMETRIC CATAYLTIC REACTIONS | PENN STATE RES FOUND (US) | 2005-06-15 | — | — | EP | disclosed |
| CN-1610688-A | Ortho-substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions | PENN STATE RES FOUND (US) | 2005-04-27 | — | — | CN | disclosed |
| US-6855657-B2 | Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions | THE PENN STATE RESEARCH FOUNDATION (US) | 2005-02-15 | — | — | US | disclosed |
| US-20040068126-A1 | Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions | THE PENN STATE RESEARCH FOUNDATION | 2004-04-08 | — | — | US | disclosed |
| US-6653485-B2 | Particularly effective in Ru-catalyzed asymmetric hydrogenation of beta-ketoesters to beta-hydroxyesters and ruthenium-catalyzed asymmetric hydrogenation of enamides to beta amino acids; catalyst selectivity | THE PENN STATE RESEARCH FOUNDATION | 2003-11-25 | — | — | US | disclosed |
| EP-1341797-A1 | ORTHO SUBSTITUTED CHIRAL PHOSPHINES AND PHOSPHINITES AND THEIR USE IN ASYMMETRIC CATAYLTIC REACTIONS | THE PENN STATE RESEARCH FOUNDATION (US) | 2003-09-10 | — | — | EP | disclosed |
| US-20020128501-A1 | Particularly effective in Ru-catalyzed asymmetric hydrogenation of beta-ketoesters to beta-hydroxyesters and ruthenium-catalyzed asymmetric hydrogenation of enamides to beta amino acids; catalyst selectivity | THE PENN STATE RESEARCH FOUNDATION | 2002-09-12 | — | — | US | disclosed |
| WO-2002040491-A1 | ORTHO SUBSTITUTED CHIRAL PHOSPHINES AND PHOSPHINITES AND THEIR USE IN ASYMMETRIC CATAYLTIC REACTIONS | THE PENN STATE RESEARCH FOUNDATION (US) | 2002-05-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040068126-A1 | Ortho substituted chiral phosphines and phosphinites and their use in asymmetric catalytic reactions | BCKDK, PDK3, HCK | HTT 3022/4885L3MBTL1 1850/4885KMT2A 975/4885 |
| US-20020128501-A1 | Particularly effective in Ru-catalyzed asymmetric hydrogenation of beta-ketoesters to beta-hydroxyesters and ruthenium-catalyzed asymmetric hydrogenation of enamides to beta amino acids; catalyst selectivity | HRH4, BCKDK, HRH3 | HTT 2205/4885L3MBTL1 1954/4885KMT2A 1234/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.