Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.66 |
| ▸ | HPGD | P15428 | 2/20 | 0.66 |
| ▸ | LMNA | P02545 | 1/20 | 0.66 |
| ▸ | GLA | P06280 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.66 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.63 |
| ▸ | HTR1D | P28221 | 4/20 | 0.60 |
| ▸ | HTR1B | P28222 | 4/20 | 0.60 |
| ▸ | HTR1A | P08908 | 2/20 | 0.60 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.52 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.52 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | PPARD | Q03181 | 1/20 | 0.51 |
| ▸ | PPARA | Q07869 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27099115 | 0.86 | ALDH1A1 (0.68) | TSHRALDH1A1HPGDLMNAGLA | |
| SCHEMBL12013054 | 0.85 | HTR1D (0.73) | HTR1DHTR1BHTR1AGABRA1GABRB2 | |
| SCHEMBL3024972 | 0.85 | HPGD (0.66) | TSHRALDH1A1HPGDLMNAGLA | |
| SCHEMBL5337098 | 0.85 | TSHR (0.66) | TSHRALDH1A1HPGDLMNAGLA | |
| SCHEMBL6242131 | 0.85 | ALDH1A1 (0.66) | TSHRALDH1A1HPGDLMNAGLA | |
| SCHEMBL10174674 | 0.84 | HTR1D (0.56) | KDM4EHTR1DHTR1BHTR1AGABRA1 | |
| SCHEMBL3037728 | 0.82 | HTR1D (0.57) | TSHRALDH1A1LMNANFKB1PMP22 | |
| SCHEMBL29244383 | 0.82 | TSHR (0.62) | TSHRALDH1A1HPGDLMNAGLA | |
| SCHEMBL6116786 | 0.81 | TSHR (0.69) | TSHRALDH1A1HPGDLMNAGLA | |
| SCHEMBL5471441 | 0.81 | HTR1D (0.67) | HTR1DHTR1BHTR1AGABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107258-A1 | Auxinic analogues of indole-3-acetic acid | Life Technologies Corporation | 2005-05-19 | — | — | US | claimed |
| US-20030087762-A1 | Auxinic analogues of indole-3-acetic acid | LIFE TECHNOLOGIES, INC. | 2003-05-08 | — | — | US | claimed |
| EP-0866850-A4 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | LIFE TECHNOLOGIES INC (US) | 2000-11-22 | — | — | EP | claimed |
| EP-0866850-A1 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | LIFE TECHNOLOGIES, INC. (US) | 1998-09-30 | — | — | EP | claimed |
| WO-1997020034-A9 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | — | 1997-10-16 | — | — | WO | claimed |
| WO-1997020034-A1 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | LIFE TECHNOLOGIES, INC. (US) | 1997-06-05 | — | — | WO | claimed |
| CN-118338898-A | Small molecule inhibitors of oncogenic CHD1L with preclinical anti-colorectal cancer activity | 科罗拉多州立大学董事会（法人团体） | 2024-07-12 | — | — | CN | disclosed |
| US-20230103444-A1 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | UNITED STATES GOVERNMENT | 2023-04-06 | — | — | US | disclosed |
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |
| EP-3438108-B1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2022-08-10 | — | — | EP | disclosed |
| CN-109071541-B | Phenyl [ a ] indole [2,3-g ] quinolizine compound, preparation method thereof, pharmaceutical composition and application thereof | 中国科学院上海药物研究所 | 2021-06-18 | — | — | CN | disclosed |
| US-10927107-B2 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2021-02-23 | — | — | US | disclosed |
| US-20190194185-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2019-06-27 | — | — | US | disclosed |
| US-20030087762-A1 | Auxinic analogues of indole-3-acetic acid | LIFE TECHNOLOGIES, INC. | 2003-05-08 | — | — | US | disclosed |
| US-6361999-B1 | AMELIORATING DETRIMENTAL EFFECTS OF STRESS ON A PLANT OR PLANT TISSUE, SUCH AS ENVIRONMENTAL STRESS, PHYSICAL STRESS, CHEMICAL STRESS, FROM POLLUTION, CONTAMINATION, DROUGHT, AND LIGHT BY CONTACTING WITH AUXINIC INDOLE ACETIC ACID COMPOUND | LIFE TECHNOLOGIES, INC. | 2002-03-26 | — | — | US | disclosed |
| EP-0866850-A4 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | LIFE TECHNOLOGIES INC (US) | 2000-11-22 | — | — | EP | disclosed |
| EP-0866850-A1 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | LIFE TECHNOLOGIES, INC. (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997020034-A9 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | — | 1997-10-16 | — | — | WO | disclosed |
| WO-1997020034-A1 | AUXINIC ANALOGUES OF INDOLE-3-ACETIC ACID | LIFE TECHNOLOGIES, INC. (US) | 1997-06-05 | — | — | WO | disclosed |
| US-4247597-A | Electroscopic carrier particles having a carboxylic acid surface treatment | PITNEY BOWES, INC. (US) | 1981-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10927107-B2 | Phenyl [a]indole[2,3-g]quinolizine compounds, preparation method therefor, pharmaceutical composition, and applications thereof | PCSK9, PCSK7, PCSK6 | TSHR 3140/4885ALDH1A1 2606/4885HPGD 1109/4885 |
| US-20230103444-A1 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | CHD1L, CHD1, CHD9 | TSHR 2534/4885ALDH1A1 1610/4885HPGD 3065/4885 |
| US-20030087762-A1 | Auxinic analogues of indole-3-acetic acid | AADAC, AADAT, AANAT | TSHR 754/4885ALDH1A1 938/4885HPGD 1986/4885 |
| US-20190194185-A1 | PHENYL [A]INDOLE[2,3-G]QUINOLIZINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF | PCSK9, PCSK7, PCSK6 | TSHR 3140/4885ALDH1A1 2606/4885HPGD 1109/4885 |
| US-20050107258-A1 | Auxinic analogues of indole-3-acetic acid | AADAC, AADAT, AANAT | TSHR 795/4885ALDH1A1 1052/4885HPGD 2317/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.