SCHEMBL6132679

SCHEMBL6132679

COCCCCCCCCCS(=O)(=O)c1ccc(-c2nc(-c3ccc(C(=O)O)cc3)no2)cc1

nearest known ligand 0.48

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.44
CA2 P00918 4/20 0.44
CA9 Q16790 4/20 0.44
CA12 O43570 2/20 0.44
CA1 P00915 2/20 0.44
HDAC4 P56524 1/20 0.42
HDAC6 Q9UBN7 1/20 0.42
RARA P10276 2/20 0.41
RARB P10826 2/20 0.41
RARG P13631 2/20 0.41
TPH1 P17752 2/20 0.41
MAPT P10636 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6132909 1.00 NR1H4 (0.44) NR1H4CA2CA9CA12CA1
SCHEMBL6132384 0.91 MAPT (0.52) CA2CA9CA12CA1HDAC4
SCHEMBL6132386 0.91 MAPT (0.52) CA2CA9CA12CA1HDAC4
SCHEMBL6132385 0.89 RARB (0.47) NR1H4CA2CA9RARARARB
SCHEMBL7420362 0.84 ENPP3 (0.40) RARB
SCHEMBL6133069 0.84 TSHR (0.46) CA2CA9CA12CA1HDAC4
SCHEMBL6132571 0.83 RARB (0.55) NR1H4RARBTPH1MAPT
SCHEMBL6132663 0.83 RARB (0.55) NR1H4RARBTPH1MAPT
SCHEMBL6132885 0.79 HDAC4 (0.47) CA2CA9CA12CA1HDAC4
SCHEMBL6133194 0.79 HDAC4 (0.47) CA2CA9CA12CA1HDAC4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6884868-B1 Cyclic hexapeptides having antibiotic activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2005-04-26 US disclosed