Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | CLK1 | P49759 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.43 |
| ▸ | CASR | P41180 | 4/20 | 0.43 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TERT | O14746 | 2/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6134653 | 0.92 | ALDH1A1 (0.45) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| Hydrochloric Acid SCHEMBL6133940 | 0.91 | ALDH1A1 (0.61) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| Hydrochloric Acid SCHEMBL6133484 | 0.91 | ALDH1A1 (0.49) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| Hydrochloric Acid SCHEMBL6134178 | 0.89 | ALDH1A1 (0.47) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| SCHEMBL6133773 | 0.86 | PTGS2 (0.48) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| Hydrochloric Acid SCHEMBL6133533 | 0.86 | PTGS2 (0.48) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| SCHEMBL6133304 | 0.85 | PTGS2 (0.52) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| SCHEMBL6133403 | 0.85 | PTGS2 (0.47) | ALDH1A1NPC1TSHRCLK1RAB9A | |
| SCHEMBL6133428 | 0.84 | ALDH1A1 (0.47) | ALDH1A1LMNAADORA2AADORA1MAPT | |
| Hydrochloric Acid SCHEMBL6133420 | 0.84 | PTGS2 (0.47) | ALDH1A1NPC1TSHRCLK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | ALDH1A1 630/4885NPC1 2391/4885TSHR 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.