Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 8/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.46 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133773 | 0.85 | PTGS2 (0.48) | LMNAADORA2AADORA1NPC1ALDH1A1 | |
| SCHEMBL6134311 | 0.85 | HPGD (0.41) | KMT2AHPGDADORA2AMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6133533 | 0.85 | PTGS2 (0.48) | LMNAADORA2AADORA1NPC1ALDH1A1 | |
| SCHEMBL6133465 | 0.84 | HSD17B10 (0.39) | KDM5BKMT2AADORA2AADORA1MEN1 | |
| SCHEMBL6133850 | 0.83 | HPGD (0.45) | KMT2ALMNAHPGDMEN1SMN1; SMN2 | |
| SCHEMBL6133793 | 0.83 | HSD17B10 (0.46) | KMT2AMEN1SMN1; SMN2KDM4E | |
| SCHEMBL6134990 | 0.83 | MAPT (0.42) | KMT2ALMNAMEN1NPC1ALDH1A1 | |
| SCHEMBL6135410 | 0.83 | RAB9A (0.44) | KMT2ALMNAHPGDMEN1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL6133484 | 0.83 | ALDH1A1 (0.49) | KMT2ALMNAADORA2AADORA1KDM4E | |
| SCHEMBL6133811 | 0.83 | NPC1 (0.40) | HPGDADORA2AADORA1SMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | KDM5B 3722/4885KMT2A 2724/4885LMNA 4780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.