Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 13/20 | 0.51 |
| ▸ | CASP1 | P29466 | 13/20 | 0.51 |
| ▸ | CASP7 | P55210 | 13/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 12/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.51 |
| ▸ | USP2 | O75604 | 10/20 | 0.51 |
| ▸ | MEN1 | O00255 | 6/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.44 |
| ▸ | GLA | P06280 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133837 | 0.86 | ALDH1A1 (0.53) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL6134360 | 0.83 | LMNA (0.47) | MEN1KMT2ALMNAKDM4EPOLB | |
| SCHEMBL6133247 | 0.80 | CASP1 (0.43) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL6134316 | 0.79 | HRH3 (0.43) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL6133485 | 0.74 | ALDH1A1 (0.44) | ALDH1A1CYP1A2CASP1CASP7HSD17B10 | |
| SCHEMBL11144982 | 0.73 | HRH3 (0.54) | MEN1KMT2AGLATSHRKDM4E | |
| SCHEMBL6133620 | 0.72 | ADORA1 (0.52) | MEN1KMT2ATSHRMAPK1LMNA | |
| SCHEMBL6134537 | 0.72 | RPS6KA3 (0.48) | KMT2ALMNAHRH3 | |
| SCHEMBL11405317 | 0.72 | HRH3 (0.52) | MEN1KMT2AGLATSHRKDM4E | |
| SCHEMBL6134043 | 0.71 | ADORA1 (0.53) | KMT2AHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ASTELLAS PHARMA INC. (JP) | 2005-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043315-A1 | Aminopyrimidine compounds, processes for their preparation and pharmaceutical compositions containing them | ADORA2B, ADORA2A, ADORA1 | ALDH1A1 801/4885CYP1A2 1170/4885CASP1 4379/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.