Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133281 | 0.99 | PTGS2 (0.43) | HPGDALDH1A1KDM4EKMT2APTGS2 | |
| SCHEMBL6134065 | 0.92 | ALDH1A1 (0.53) | HPGDALDH1A1KDM4EKMT2APTGS2 | |
| SCHEMBL6133806 | 0.92 | PTGS2 (0.43) | HPGDALDH1A1KDM4EKMT2APTGS2 | |
| SCHEMBL6133850 | 0.91 | HPGD (0.45) | HPGDALDH1A1KDM4EKMT2APTGS2 | |
| SCHEMBL6133292 | 0.91 | TSHR (0.42) | HPGDALDH1A1KDM4EKMT2APTGS2 | |
| SCHEMBL6133241 | 0.88 | SMN1; SMN2 (0.44) | HPGDALDH1A1KDM4EKMT2APTGS2 | |
| SCHEMBL6133813 | 0.85 | ALOX15 (0.46) | ALDH1A1KDM4EKMT2APTGS2TSHR | |
| SCHEMBL6133425 | 0.84 | RET (0.41) | ALDH1A1KDM4EKMT2AMAPTNPC1 | |
| SCHEMBL6134642 | 0.83 | TP53 (0.41) | HPGDALDH1A1KDM4ETSHRHSD17B10 | |
| SCHEMBL6133840 | 0.83 | PTGS2 (0.50) | HPGDALDH1A1KDM4EKMT2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | HPGD 1177/4885ALDH1A1 630/4885KDM4E 3814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.