Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.47 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.40 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | APAF1 | O14727 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | NSD2 | O96028 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6133773 | 0.91 | PTGS2 (0.48) | PTGS2ACHEACP1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6133533 | 0.90 | PTGS2 (0.48) | PTGS2ACHEACP1CYP3A4CYP2D6 | |
| Hydrochloric Acid SCHEMBL6133446 | 0.87 | ALDH1A1 (0.44) | PTGS2MAPTMEN1CYP3A4GAA | |
| SCHEMBL6133403 | 0.86 | PTGS2 (0.47) | PTGS2RAD52ACP1MAPTMEN1 | |
| SCHEMBL6133360 | 0.86 | PTGS2 (0.42) | PTGS2MAPTGAAHTTKDM4E | |
| Hydrochloric Acid SCHEMBL6133420 | 0.85 | PTGS2 (0.47) | PTGS2RAD52ACP1MAPTMEN1 | |
| Hydrochloric Acid SCHEMBL6134653 | 0.84 | ALDH1A1 (0.45) | PTGS2ACHEMAPTMEN1CYP3A4 | |
| SCHEMBL6133651 | 0.84 | NPC1 (0.51) | PTGS2MAPTALOX15SMN1; SMN2NPC1 | |
| SCHEMBL6133532 | 0.83 | PTGS2 (0.44) | PTGS2MAPTGAAHTTALDH1A1 | |
| SCHEMBL6136106 | 0.83 | MAPT (0.50) | PTGS2MAPTMEN1GAAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | PTGS2 1262/4885RAD52 3724/4885ACHE 3391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.