Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 4/20 | 0.42 |
| ▸ | XIAP | P98170 | 3/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | MERTK | Q12866 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.37 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6134027 | 0.93 | PTGS2 (0.40) | PTGS2XIAPADORA2AMERTKADORA1 | |
| SCHEMBL6133383 | 0.92 | ALDH1A1 (0.43) | PTGS2XIAPPTPN1PTPN2CDC25B | |
| SCHEMBL6133532 | 0.92 | PTGS2 (0.44) | PTGS2XIAPADORA2AADORA1GAA | |
| SCHEMBL6136106 | 0.89 | MAPT (0.50) | PTGS2XIAPADORA2AADORA1PTPN1 | |
| SCHEMBL6133821 | 0.88 | TGFBR1 (0.44) | PTGS2XIAPADORA2AADORA1GAA | |
| SCHEMBL6134205 | 0.86 | XIAP (0.43) | PTGS2XIAPADORA2AADORA1MAPT | |
| SCHEMBL6133970 | 0.86 | PTGS2 (0.47) | PTGS2GAAMAPTKDM4EALDH1A1 | |
| SCHEMBL6133314 | 0.86 | HIF1A (0.41) | PTGS2XIAPADORA2AADORA1MAPT | |
| SCHEMBL6133401 | 0.85 | XIAP (0.42) | PTGS2XIAPADORA2AMERTKADORA1 | |
| Bromide SCHEMBL6134102 | 0.85 | XIAP (0.42) | PTGS2XIAPADORA2AADORA1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | ASTELLAS PHARMA INC. (JP) | 2005-01-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050004134-A1 | Thiazole derivative and pharmaceutical use thereof | MC2R, CYP2C9, OXTR | PTGS2 1262/4885XIAP 4881/4885ADORA2A 635/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.