Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | APLNR | P35414 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022821 | 0.86 | GPR84 (0.47) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL17371365 | 0.79 | ALOX15 (0.57) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL25239244 | 0.78 | HASPIN (0.46) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL14834735 | 0.78 | KMT2A (0.41) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL12656989 | 0.78 | NPC1 (0.40) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL16920981 | 0.77 | ALDH1A1 (0.47) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL2558503 | 0.76 | ALOX15 (0.39) | HPGDNPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL1253257 | 0.76 | ALDH1A1 (0.45) | HPGDSMN1; SMN2APLNRALDH1A1LMNA | |
| SCHEMBL5928189 | 0.75 | ALDH1A1 (0.33) | HPGDALOX15KMT2AALDH1A1NPSR1 | |
| SCHEMBL12744426 | 0.75 | ALOX15 (0.36) | HPGDNPC1RAB9ASMN1; SMN2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1385830-A4 | SULFONAMIDES | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| US-20040152895-A1 | Sulfonamides | SMITHKLINE BEECHAM CORPORATION | 2004-08-05 | — | — | US | disclosed |
| EP-1385830-A1 | SULFONAMIDES | SmithKline Beecham Corporation (US) | 2004-02-04 | — | — | EP | disclosed |
| WO-2002090337-A1 | SULFONAMIDES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152895-A1 | Sulfonamides | UTS2R, PRSS2, STS | HPGD 1890/4885NPC1 3410/4885RAB9A 4202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.