Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | DCLRE1B | Q9H816 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.38 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.38 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.37 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | CTSA | P10619 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.35 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL812909 | 0.91 | ESR2 (0.48) | ESR2DCLRE1BSLC6A9CNR2MAPT | |
| SCHEMBL7102811 | 0.86 | SLC6A9 (0.39) | ESR2DCLRE1BSLC6A9CNR2MAPT | |
| SCHEMBL6049534 | 0.74 | TDP1 (0.49) | MAPTFFAR1 | |
| SCHEMBL23706391 | 0.72 | ESR2 (0.43) | ESR2DCLRE1BSLC6A9MAPTMDM2 | |
| SCHEMBL23717944 | 0.69 | ESR2 (0.48) | ESR2DCLRE1BMAPTALOX5 | |
| SCHEMBL7248442 | 0.69 | ESR2 (0.51) | ESR2DCLRE1BSLC6A9MAPTFFAR1 | |
| SCHEMBL23717575 | 0.69 | ESR2 (0.42) | ESR2DCLRE1BSLC6A9CNR2MAPT | |
| SCHEMBL30168599 | 0.69 | ESR2 (0.42) | ESR2DCLRE1BSLC6A9CNR2MAPT | |
| SCHEMBL10024258 | 0.68 | DCLRE1B (0.57) | ESR2DCLRE1BMDM2PTGER4PTGER2 | |
| SCHEMBL10024224 | 0.68 | DCLRE1B (0.61) | ESR2DCLRE1BPTGER4PTGER2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8987500-B2 | 4-biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2015-03-24 | — | — | US | disclosed |
| US-20140039215-A1 | 4-Biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2014-02-06 | — | — | US | disclosed |
| US-8586783-B2 | 4-biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2013-11-19 | — | — | US | disclosed |
| US-20130018202-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2013-01-17 | — | — | US | disclosed |
| US-8168566-B2 | 4-biphenyl-substituted pyrazolidin-3,5-dione derivatives | BAYER CROPSCIENCE AG (DE) | 2012-05-01 | — | — | US | disclosed |
| US-8119566-B2 | use as pesticides and/or herbicides and/or microbicides; for the selective control of weeds; synergistic; low application rates and concentrations; in particular in cereals (especially wheat) | BAYER CROPSCIENCE AG (DE) | 2012-02-21 | — | — | US | disclosed |
| US-20120040963-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | BAYER CROPSCIENCE AG (DE) | 2012-02-16 | — | — | US | disclosed |
| US-20080188371-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | BAYER CROPSCIENCE AKTIENGESELLSCHAFT (DE) | 2008-08-07 | — | — | US | disclosed |
| US-6806264-B2 | PESTICIDES AND HERBICIDES; WOOD PROTECTANTS | BAYER AKTIENGESELLSCHAFT (DE) | 2004-10-19 | — | — | US | disclosed |
| US-20040127365-A1 | Arylphenyl-substituted cyclic ketoenols | LIEB FOLKER (DE) | 2004-07-01 | — | — | US | disclosed |
| US-6693092-B2 | HERBICIDES; PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 2004-02-17 | — | — | US | disclosed |
| US-20030073851-A1 | Arylphenyl-substituted cyclic ketoenols | LIEB FOLKER (DE) | 2003-04-17 | — | — | US | disclosed |
| US-6458965-B1 | HERBICIDES, ANTIGROWTH AGENTS AND SURFACTANTS FOR WOOD PRESERVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2002-10-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140039215-A1 | 4-Biphenyl-substituted pyrazolidin-3,5-dione derivatives | DDT, CYP4X1, HPD | ESR2 2752/4885DCLRE1B 1271/4885SLC6A9 3355/4885 |
| US-20030073851-A1 | Arylphenyl-substituted cyclic ketoenols | KCNE1, CYP2E1, CYP21A2 | ESR2 1416/4885DCLRE1B 1957/4885SLC6A9 2615/4885 |
| US-20120040963-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | DDT, CYP4X1, HPD | ESR2 2752/4885DCLRE1B 1271/4885SLC6A9 3355/4885 |
| US-20080188371-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | DDT, CYP4X1, HPD | ESR2 2752/4885DCLRE1B 1271/4885SLC6A9 3355/4885 |
| US-20130018202-A1 | 4-Biphenyl-Substituted Pyrazolidin-3,5-Dione Derivatives | DDT, CYP4X1, HPD | ESR2 2752/4885DCLRE1B 1271/4885SLC6A9 3355/4885 |
| US-20040127365-A1 | Arylphenyl-substituted cyclic ketoenols | KCNE1, CYP2E1, CYP21A2 | ESR2 1416/4885DCLRE1B 1957/4885SLC6A9 2615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.