SCHEMBL6135801

SCHEMBL6135801

Cn1c2cc(Nc3ccccc3)ccc2c2ccc(Nc3ccccc3)cc21

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.50
HSD17B10 Q99714 4/20 0.50
L3MBTL1 Q9Y468 4/20 0.50
TSHR P16473 3/20 0.50
TDP1 Q9NUW8 3/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
ALOX12 P18054 3/20 0.50
MAPT P10636 3/20 0.50
ALOX15 P16050 2/20 0.50
PTGS1 P23219 1/20 0.50
SLC6A2 P23975 1/20 0.50
MAPK1 P28482 1/20 0.50
PTGS2 P35354 1/20 0.50
HTR2B P41595 1/20 0.50
AR P10275 1/20 0.50
APP P05067 1/20 0.49
CYP3A4 P08684 4/20 0.47
HPGD P15428 2/20 0.47
NPSR1 Q6W5P4 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21992226 0.87 RXRA (0.51) ALDH1A1HSD17B10L3MBTL1TSHRMEN1
SCHEMBL28434648 0.81 MAPT (0.60) ALDH1A1HSD17B10L3MBTL1TSHRTDP1
SCHEMBL29371968 0.81 MAOB (0.39) ALDH1A1HSD17B10MEN1KMT2AMAPT
SCHEMBL6135449 0.79 L3MBTL1 (0.50) ALDH1A1HSD17B10L3MBTL1TSHRTDP1
SCHEMBL9912987 0.79 ALDH1A1 (0.48) ALDH1A1HSD17B10L3MBTL1TSHRTDP1
SCHEMBL24865481 0.77 TRIM24 (0.61) ALDH1A1HSD17B10MEN1KMT2AMAPT
SCHEMBL21939629 0.76 KDM1A (0.71) ALDH1A1HSD17B10TDP1MEN1KMT2A
SCHEMBL30170400 0.75 L3MBTL1 (0.60) ALDH1A1HSD17B10L3MBTL1TSHRTDP1
SCHEMBL16891270 0.75 L3MBTL1 (0.60) ALDH1A1HSD17B10L3MBTL1TSHRTDP1
SCHEMBL31743134 0.74 BRPF1 (0.56) ALDH1A1HSD17B10L3MBTL1TSHRTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050067951-A1 For example, N,N'-bis-(4'-(N-triphenylmethyl)-phenyl)-N-naphth-1-yl-amino)-bi-phenylyl)-N,N'-bisphenyl-2,7-amino-9-phenylcarbazole; hole transfer material SENSIENT IMAGING TECHNOLOGIES GMBH 2005-03-31 US disclosed
EP-1470100-A1 TRIARYLAMINE DERIVATIVES AND THE USE THEREOF IN ORGANIC ELECTROLUMINESCENT AND ELECTROPHOTOGRAPHIC DEVICES Sensient Imaging Technologies GmbH (DE) 2004-10-27 EP disclosed
WO-2003064373-A1 TRIARYLAMINE DERIVATIVES AND THE USE THEREOF IN ORGANIC ELECTROLUMINESCENT AND ELECTROPHOTOGRAPHIC DEVICES SENSIENT IMAGING TECHNOLOGIES GMBH (DE) 2003-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050067951-A1 For example, N,N'-bis-(4'-(N-triphenylmethyl)-phenyl)-N-naphth-1-yl-amino)-bi-phenylyl)-N,N'-bisphenyl-2,7-amino-9-phenylcarbazole; hole transfer material NAT1, NUCB2, PNN ALDH1A1 2424/4885HSD17B10 1653/4885L3MBTL1 534/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.