SCHEMBL6136884

SCHEMBL6136884

O=C(O)c1ccc(-c2nn(-c3ccc(C(=O)O)cc3)c3ccccc23)cc1

nearest known ligand 0.68

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RORC P51449 14/20 0.66
RARG P13631 6/20 0.57
HPGD P15428 1/20 0.55
PTGER1 P34995 3/20 0.52
HTT P42858 1/20 0.51
PPARG P37231 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137028 0.93 RORC (0.59) RORCRARGHPGDPTGER1HTT
Hydrochloric Acid SCHEMBL6136775 0.92 RORC (0.57) RORCRARGHPGDPTGER1HTT
Hydrochloric Acid SCHEMBL6136946 0.92 RORC (0.57) RORCRARGHPGDPTGER1HTT
SCHEMBL6136876 0.89 RORC (0.54) RORCRARG
SCHEMBL6136897 0.89 RORC (0.54) RORCRARG
SCHEMBL6136871 0.88 RORC (0.53) RORCRARGHPGDHTT
SCHEMBL6137351 0.87 RORC (0.50) RORCRARGHPGDPTGER1
SCHEMBL6137025 0.84 F2RL3 (0.51) RORCRARGHPGD
SCHEMBL6136923 0.83 MAPK8 (0.55) RORCRARGHPGD
SCHEMBL6136872 0.82 RORC (0.47) RORCRARGHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050227299-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening AUER MANFRED 2005-10-13 US disclosed
EP-1140856-B1 FLUORESCENT DYES FOR SOLID PHASE AND SOLUTION PHASE SCREENING NOVARTIS AG (CH) 2005-04-27 EP disclosed
EP-1140856-A1 FLUORESCENT DYES FOR SOLID PHASE AND SOLUTION PHASE SCREENING Novartis AG (CH) 2001-10-10 EP disclosed
US-20010005752-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening AUER MANFRED (AT) 2001-06-28 US disclosed
US-6207831-B1 A BENZOPYRAZOLE COMPOUND NOVARTIS AG (CH) 2001-03-27 US disclosed
WO-2000037448-A1 FLUORESCENT DYES FOR SOLID PHASE AND SOLUTION PHASE SCREENING NOVARTIS AG (CH) 2000-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010005752-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening SLC43A1, CUTA, ANXA1 RORC 4824/4885RARG 3934/4885HPGD 4341/4885
US-20050227299-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening SLCO1A2, ABCG2, SLCO1B1 RORC 3437/4885RARG 1976/4885HPGD 2745/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.