SCHEMBL6137069

SCHEMBL6137069

C=CCOC(=O)c1ccc(-c2nn(-c3ccc(C(=O)ON4C(=O)CCC4=O)cc3)c3ccccc23)cc1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 1/20 0.43
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
SNCA P37840 1/20 0.35
ALDH1A1 P00352 1/20 0.35
HPGD P15428 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.35
RORC P51449 4/20 0.35
KDM4E B2RXH2 1/20 0.35
HSD17B10 Q99714 1/20 0.34
CYP3A4 P08684 1/20 0.34
MAPT P10636 1/20 0.34
TDP1 Q9NUW8 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
GABRP O00591 1/20 0.34
GABRD O14764 1/20 0.34
GABRA1 P14867 1/20 0.34
GABRB1 P18505 1/20 0.34
GABRG2 P18507 1/20 0.34
GABRB3 P28472 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137025 0.86 F2RL3 (0.51) F2RL3MEN1KMT2AHPGDRORC
SCHEMBL6137351 0.68 RORC (0.50) F2RL3ALDH1A1HPGDRORCHSD17B10
SCHEMBL6136810 0.68 ALDH1A1 (0.54) F2RL3MEN1KMT2AALDH1A1HPGD
SCHEMBL4872950 0.67 SMN1; SMN2 (0.54) KMT2AHPGDSMN1; SMN2KDM4EMAPT
SCHEMBL13455758 0.66 SMN1; SMN2 (0.44) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
SCHEMBL2346908 0.65 CYP3A4 (0.61) MEN1KMT2ASNCAALDH1A1SMN1; SMN2
SCHEMBL16797199 0.65 F2RL3 (0.54) F2RL3MEN1KMT2AALDH1A1HPGD
SCHEMBL461801 0.65 SNCA (0.61) MEN1KMT2ASNCAALDH1A1KDM4E
SCHEMBL300884 0.65 CA12 (0.42) MEN1KMT2AALDH1A1HPGDSMN1; SMN2
Hydrochloric Acid SCHEMBL6136775 0.64 RORC (0.57) HPGDSMN1; SMN2RORCMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050227299-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening AUER MANFRED 2005-10-13 US disclosed
EP-1140856-B1 FLUORESCENT DYES FOR SOLID PHASE AND SOLUTION PHASE SCREENING NOVARTIS AG (CH) 2005-04-27 EP disclosed
EP-1140856-A1 FLUORESCENT DYES FOR SOLID PHASE AND SOLUTION PHASE SCREENING Novartis AG (CH) 2001-10-10 EP disclosed
US-20010005752-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening AUER MANFRED (AT) 2001-06-28 US disclosed
WO-2000037448-A1 FLUORESCENT DYES FOR SOLID PHASE AND SOLUTION PHASE SCREENING NOVARTIS AG (CH) 2000-06-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010005752-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening SLC43A1, CUTA, ANXA1 F2RL3 4196/4885MEN1 2066/4885KMT2A 3039/4885
US-20050227299-A1 Fluorescent dyes (AIDA) for solid phase and solution phase screening SLCO1A2, ABCG2, SLCO1B1 F2RL3 2995/4885MEN1 2470/4885KMT2A 1813/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.