Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2BTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3MPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PPARGSLC6A2SLC6A3SLC6A4SMOTYK2pol
The experimentally established mechanism targets of Maleic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.43 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 known ✓ | P35367 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MCOLN3 | Q8TDD5 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | PGR | P06401 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | MLYCD | O95822 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL458409 | 0.90 | NPSR1 (0.59) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL31125741 | 0.88 | NPSR1 (0.57) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3759428 | 0.88 | NPSR1 (0.57) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| SCHEMBL1477108 | 0.85 | NPSR1 (0.54) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| Fumaric Acid SCHEMBL29772361 | 0.82 | OPRM1 (0.47) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| SCHEMBL30268201 | 0.79 | NPSR1 (0.66) | NPSR1HPGDMCOLN3ALDH1A1MAPT | |
| SCHEMBL29173031 | 0.79 | TRPM8 (0.45) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| SCHEMBL6383907 | 0.76 | NPSR1 (0.50) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| SCHEMBL6383709 | 0.76 | NPSR1 (0.50) | NPSR1TRPM8HPGDMCOLN3ALDH1A1 | |
| SCHEMBL154606 | 0.76 | TRPM8 (0.53) | NPSR1TRPM8HPGDALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1411935-A4 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM IND CO LTD (KR) | 2005-11-09 | — | — | EP | disclosed |
| EP-1411935-A1 | USE OF 4- (4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARMACEUTICAL INDUSTRIAL CO. LTD. (KR) | 2004-04-28 | — | — | EP | disclosed |
| WO-2003007947-A1 | USE OF 4-[(4-THIAZOLYL)PHENOXL] ALKOXY-BENZAMIDINE DERIVATIVES FOR TREATMENT OF OSTEOPOROSIS | DONG WHA PHARM. IND. CO., LTD. (KR) | 2003-01-30 | — | — | WO | disclosed |