SCHEMBL6137717

SCHEMBL6137717

CCOc1ccc(C(=O)N(CCSCc2ccccc2)C(=N)N)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX12 P18054 2/20 0.47
L3MBTL1 Q9Y468 2/20 0.47
CYP1A2 P05177 1/20 0.47
CYP3A4 P08684 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47
HTT P42858 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
MAPT P10636 5/20 0.45
LMNA P02545 2/20 0.45
PARP10 Q53GL7 2/20 0.44
PRSS1 P07477 1/20 0.44
PRSS2 P07478 1/20 0.44
PRSS3 P35030 1/20 0.44
NPC1 O15118 2/20 0.43
RAB9A P51151 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
ALDH1A1 P00352 3/20 0.42
SCN5A Q14524 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137598 0.73 DRD2 (0.53) L3MBTL1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL6137840 0.72 SCN5A (0.49) L3MBTL1MAPTLMNAPARP10PRSS1
SCHEMBL6003647 0.71 LPAR1 (0.53) ALOX12L3MBTL1HTTNPSR1MAPT
SCHEMBL4628981 0.71 MAPT (0.57) ALOX12L3MBTL1CYP1A2CYP3A4CYP2D6
SCHEMBL6137828 0.71 ACHE (0.56) ALOX12L3MBTL1HTTNPSR1NPC1
SCHEMBL15778908 0.68 PARP10 (0.51) L3MBTL1MAPTLMNAPARP10PRSS1
Benzamide SCHEMBL5531824 0.68 PARP10 (0.86) L3MBTL1CYP3A4CYP2C19MAPTLMNA
SCHEMBL8582839 0.68 HPGD (0.44) NPC1RAB9AALDH1A1
SCHEMBL6137876 0.67 PARP10 (0.47) ALOX12L3MBTL1CYP1A2CYP3A4CYP2D6
SCHEMBL6137813 0.67 TP53 (0.46) MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1032556-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE INC (US) 2005-02-02 EP claimed
EP-1032556-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 2000-09-06 EP claimed
WO-1999020599-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 1999-04-29 WO claimed