Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.47 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137957 | 0.74 | TRPM8 (0.40) | NPC1RAB9AMAPTALDH1A1KMT2A | |
| SCHEMBL28425736 | 0.71 | HPGD (0.48) | PARP10PRSS1PRSS2PRSS3NPC1 | |
| SCHEMBL28809795 | 0.71 | MAPT (0.56) | PARP10NPC1RAB9ALMNAMAPT | |
| SCHEMBL6138040 | 0.71 | MAPT (0.52) | PARP10PRSS1PRSS2PRSS3NPC1 | |
| SCHEMBL4628567 | 0.69 | KMT2A (0.53) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| Benzamide SCHEMBL5531824 | 0.67 | PARP10 (0.86) | PARP10PRSS1PRSS2PRSS3NPC1 | |
| SCHEMBL6137717 | 0.67 | ALOX12 (0.47) | PARP10PRSS1PRSS2PRSS3NPC1 | |
| SCHEMBL9627587 | 0.67 | SIGMAR1 (0.42) | LMNAKMT2AHPGDCYP1A2CYP3A4 | |
| SCHEMBL9388919 | 0.67 | ALDH1A1 (0.66) | PARP10PRSS1PRSS2PRSS3NPC1 | |
| Hydrochloric Acid SCHEMBL11835550 | 0.66 | PARP10 (0.53) | PARP10PRSS1PRSS2PRSS3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032556-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-02 | — | — | EP | disclosed |
| EP-1032556-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999020599-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-29 | — | — | WO | disclosed |