SCHEMBL6137828

SCHEMBL6137828

COc1ccc(C(=O)N(Cc2ccccc2)C(=N)N)cc1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 1/20 0.56
TDP1 Q9NUW8 3/20 0.53
L3MBTL1 Q9Y468 2/20 0.53
MEN1 O00255 1/20 0.53
ALDH1A1 P00352 1/20 0.53
ALOX12 P18054 1/20 0.53
HTT P42858 1/20 0.53
KMT2A Q03164 1/20 0.53
NPSR1 Q6W5P4 1/20 0.53
GPR55 Q9Y2T6 1/20 0.53
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
LPAR1 Q92633 2/20 0.52
LPAR5 Q9H1C0 2/20 0.52
TSHR P16473 2/20 0.50
KDM4E B2RXH2 1/20 0.50
HPGD P15428 1/20 0.50
LIMK2 P53671 1/20 0.49
PTGES O14684 1/20 0.49
TAS2R14 Q9NYV8 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137702 0.85 MEN1 (0.47) L3MBTL1MEN1ALDH1A1KMT2ANPC1
SCHEMBL6003647 0.84 LPAR1 (0.53) TDP1L3MBTL1MEN1ALDH1A1ALOX12
SCHEMBL6137977 0.82 AGER (0.54) L3MBTL1MEN1HTTKMT2ANPC1
SCHEMBL6137845 0.81 L3MBTL1 (0.52) TDP1L3MBTL1MEN1ALDH1A1KMT2A
SCHEMBL28778943 0.81 TDP1 (0.69) ACHETDP1L3MBTL1MEN1ALDH1A1
SCHEMBL6137598 0.81 DRD2 (0.53) L3MBTL1MEN1ALDH1A1KMT2ANPC1
SCHEMBL29006698 0.80 ACHE (0.61) ACHETDP1L3MBTL1MEN1ALDH1A1
SCHEMBL6137921 0.79 KDM4E (0.45) ALDH1A1HTTNPC1RAB9ALPAR1
SCHEMBL27893832 0.77 RAB9A (0.53) ACHETDP1L3MBTL1MEN1ALDH1A1
SCHEMBL1279153 0.76 LPAR1 (0.77) ACHETDP1LPAR1LPAR5TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1032556-A4 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE INC (US) 2005-02-02 EP disclosed
EP-1032556-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 2000-09-06 EP disclosed
WO-1999020599-A1 PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE CAMBRIDGE NEUROSCIENCE, INC. (US) 1999-04-29 WO disclosed