Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.62 |
| ▸ | HTR3B | O95264 | 2/20 | 0.62 |
| ▸ | HTR3A | P46098 | 2/20 | 0.62 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.62 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.62 |
| ▸ | ADRA2A | P08913 | 6/20 | 0.61 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.61 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | FURIN | P09958 | 2/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.52 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.52 |
| ▸ | PLAU | P00749 | 2/20 | 0.52 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.52 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.52 |
| ▸ | SLC22A3 | O75751 | 1/20 | 0.52 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.50 |
| ▸ | ACR | P10323 | 1/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17590500 | 0.79 | SCN2A (0.71) | POLBPARP10SCN5ASCN2APLAU | |
| SCHEMBL4099711 | 0.77 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Hydrochloric Acid SCHEMBL5635577 | 0.75 | HTR3E (0.96) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| Hydrogen Peroxide SCHEMBL28902806 | 0.75 | KMT2A (0.70) | POLBPARP10GLA | |
| SCHEMBL125543 | 0.75 | ALDH1A3 (0.64) | POLBPARP10GLA | |
| SCHEMBL18836850 | 0.73 | PARP10 (0.46) | POLBPARP10SCN5ASCN2AGLA | |
| SCHEMBL17590302 | 0.73 | HTR3E (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL19569860 | 0.72 | ALDH1A3 (0.52) | POLBPARP10SCN5ASCN2AGLA | |
| SCHEMBL4099965 | 0.72 | ADRA2A (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL5501717 | 0.71 | P2RY6 (0.48) | POLBPARP10SCN5ASCN2AGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032556-A4 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE INC (US) | 2005-02-02 | — | — | EP | claimed |
| EP-1032556-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 2000-09-06 | — | — | EP | claimed |
| WO-1999020599-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AND METHODS OF USE | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1999-04-29 | — | — | WO | claimed |
| EP-2604595-B1 | TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOUND THAT CONTAINS SAME AND EXHIBITS ANALGESIC ACTIVITY | SHIONOGI & CO (JP) | 2016-03-16 | — | — | EP | disclosed |