Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.52 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2302759 | 0.83 | KDM4E (0.61) | KDM4EHPGDKMT2ASMN1; SMN2LMNA | |
| SCHEMBL3794388 | 0.80 | KDM4E (0.60) | KDM4EHPGDKMT2ASMN1; SMN2LMNA | |
| SCHEMBL18555777 | 0.77 | RAB9A (0.64) | KMT2ASMN1; SMN2LMNAMAPK1NPC1 | |
| SCHEMBL13210546 | 0.77 | ALDH1A1 (0.70) | KDM4EHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13930600 | 0.76 | SMO (0.58) | KDM4EHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13930689 | 0.76 | MAPT (0.70) | KDM4EHPGDKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2358142 | 0.75 | ADORA3 (0.52) | KDM4EHPGDKMT2AMEN1ALDH1A1 | |
| SCHEMBL2302615 | 0.75 | ADORA3 (0.52) | KDM4EHPGDKMT2AMEN1TP53 | |
| SCHEMBL14502187 | 0.75 | KCNH2 (0.54) | KMT2AMEN1NPC1RAB9ADGAT1 | |
| SCHEMBL2055269 | 0.75 | RAB9A (0.67) | KDM4EHPGDKMT2ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6852736-B2 | Phenoxypropanolamines, preparation and therapeutic use thereof | SANOFI-SYNTHELABO (FR) | 2005-02-08 | — | — | US | disclosed |
| EP-1242404-B1 | PHENOXYPROPANOLAMINES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI SYNTHELABO (FR) | 2004-07-07 | — | — | EP | disclosed |
| US-20030105135-A1 | Phenoxypropanolamines, preparation and therapeutic use thereof | SANOFI-AVENTIS (FR) | 2003-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030105135-A1 | Phenoxypropanolamines, preparation and therapeutic use thereof | CNR1, ADRB3, ADRB1 | KDM4E 1468/4885HPGD 2286/4885KMT2A 1643/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.