Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Betaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.30 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.30 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.30 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Betaine SCHEMBL22686151 | 0.88 | TSHR (0.40) | TSHRALDH1A1LMNAAPEX1 | |
| Betaine SCHEMBL21712604 | 0.83 | TSHR (0.36) | TSHRALDH1A1LMNAAPEX1 | |
| Betaine SCHEMBL907529 | 0.81 | TSHR (0.34) | TSHRALDH1A1LMNAAPEX1 | |
| Betaine SCHEMBL8807531 | 0.81 | BBOX1 (0.40) | TSHRALDH1A1LMNAAPEX1 | |
| Betaine SCHEMBL3113299 | 0.77 | TSHR (0.45) | TSHRALDH1A1LMNAAPEX1CHRM2 | |
| Betaine SCHEMBL7974165 | 0.77 | TSHR (0.35) | TSHRALDH1A1LMNAAPEX1 | |
| SCHEMBL9344883 | 0.73 | — | — | |
| Betaine SCHEMBL9330112 | 0.73 | TSHR (0.32) | TSHRALDH1A1LMNAAPEX1 | |
| SCHEMBL14311922 | 0.71 | TSHR (0.40) | TSHRALDH1A1LMNAAPEX1CHRM2 | |
| SCHEMBL947653 | 0.70 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5512277-A | APPLYING CATIONIC POLYMER HAVING SALT FORMING GROUP TO SKIN, PEELING OFF AFTER DRYING | KAO CORPORATION (JP) | 1996-04-30 | — | — | US | claimed |
| US-20240084186-A1 | DEVELOPMENT OF ULTRA-HIGH MOLECULAR WEIGHT (UHMW) BRANCHED BLOCK COPOLYMER SHALE INHIBITOR FOR WATER BASED DRILLING FLUID | SAUDI ARABIAN OIL COMPANY (SA) | 2024-03-14 | — | — | US | disclosed |
| US-20180289550-A1 | SYSTEMS, APPARATUSES, KITS AND METHODS FOR IMPROVED MEDICAL PROCEDURES | Advent Access Pte. Ltd. (SG) | 2018-10-11 | — | — | US | disclosed |
| WO-2018185555-A2 | SYSTEMS, APPARATUSES, KITS AND METHODS FOR IMPROVED MEDICAL PROCEDURES | Advent Access Pte. Ltd. (SG) | 2018-10-11 | — | — | WO | disclosed |
| EP-1202709-B1 | COSMETIC STRIP WITH AN AGENT FOR INDUCING A TEMPERATURE CHANGE | UNILEVER PLC (GB) | 2005-09-28 | — | — | EP | disclosed |
| US-6607719-B2 | Applying a polymer compound having a salt forming group to the skin and peeling | KAO CORPORATION (JP) | 2003-08-19 | — | — | US | disclosed |
| US-6494856-B1 | Swab deliverable actives | UNILEVER HOME & PERSONAL CARE USA, DIVISION OF CONOPCO, INC. | 2002-12-17 | — | — | US | disclosed |
| EP-0971684-B1 | KERATOTIC PLUG REMOVER | UNILEVER PLC (GB) | 2002-12-11 | — | — | EP | disclosed |
| US-6488646-B1 | Swab deliverable actives | UNILEVER HOME & PERSONAL CARE USA | 2002-12-03 | — | — | US | disclosed |
| US-20020048560-A1 | Keratotic plug remover | KAO CORPORATION (JP) | 2002-04-25 | — | — | US | disclosed |
| US-6106857-A | Fragranced cosmetic product for removal of keratotic plugs from skin pores | CHESEBROUGH-POND'S USA CO., DIVISION OF CONOPCO, INC. (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0826364-B1 | Keratotic plug remover | KAO CORP (JP) | 1999-12-29 | — | — | EP | disclosed |
| US-5993838-A | STRIP INCLUDES A FLEXIBLE SUBSTRATE SHEET ONTO WHICH A COMPOSITION CONTAINING AN ADHESIVE POLYMER IS DEPOSITED; TREATED TO BECOME DRY NON-TACKY TO THE TOUCH YET UPON BEING WETTED FOR USE THE COMPOSITION AGAIN TURNS TACKY AND MOBILE. | CHESEBROUGH-POND'S USA CO., (US) | 1999-11-30 | — | — | US | disclosed |
| US-5985300-A | PORE CLEANSING | CHESEBROUGH-POND'S USA CO. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0949275-A1 | METHOD FOR THE PURIFICATION OF IONIC POLYMERS | Kao Corporation (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5935596-A | COSMETIC; REMOVE KERATOTIC PLUGS FROM SKIN | CHESEBROUGH-POND'S USA CO. (US) | 1999-08-10 | — | — | US | disclosed |
| EP-0826364-A2 | Keratotic plug remover | KAO CORPORATION (JP) | 1998-03-04 | — | — | EP | disclosed |
| EP-0514760-B1 | Keratotic plug remover | KAO CORP (JP) | 1997-04-23 | — | — | EP | disclosed |
| US-5512277-A | APPLYING CATIONIC POLYMER HAVING SALT FORMING GROUP TO SKIN, PEELING OFF AFTER DRYING | KAO CORPORATION (JP) | 1996-04-30 | — | — | US | disclosed |
| EP-0514760-A1 | Keratotic plug remover | KAO CORPORATION (JP) | 1992-11-25 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020048560-A1 | Keratotic plug remover | KRT18, CUTA, DSG1 | TSHR 4367/4885ALDH1A1 3981/4885LMNA 2515/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.