Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 5/20 | 0.82 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.82 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.82 |
| ▸ | AKR1C4 | P17516 | 3/20 | 0.82 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.82 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.62 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MYC | P01106 | 1/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CCR6 | P51684 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141543 | 1.00 | AKR1C3 (0.82) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL6141317 | 0.87 | AKR1C3 (0.63) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL22720171 | 0.84 | TAS2R14 (0.74) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL21248526 | 0.83 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL9118458 | 0.83 | KCNMA1 (0.66) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL6813056 | 0.83 | TAS2R14 (0.77) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL18667006 | 0.82 | HCAR3 (0.72) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL1688337 | 0.82 | AKR1C3 (0.69) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL13811262 | 0.81 | MAPK1 (0.75) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 | |
| SCHEMBL16737110 | 0.81 | AKR1C3 (0.71) | AKR1C3AKR1C2AKR1B1AKR1C4AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1525183-A1 | INHIBITORS OF HCV NS5B POLYMERASE | Pharmacia & Upjohn Company LLC (US) | 2005-04-27 | — | — | EP | disclosed |
| WO-2004002940-A1 | INHIBITORS OF HCV NS5B POLYMERASE | PHARMACIA & UPJOHN COMPANY (US) | 2004-01-08 | — | — | WO | disclosed |